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Clinician Scientists

Clinician Scientists

Dr. Martin Regensburger

Clinician Scientist, MD rotation position 2017

Department of Stem Cell Biology
Prof. Winner

2011 MD, University of Regensburg

2012 M.Sc. (Neurosciences), University of Regensburg

since 2011 Resident, Department of Neurology and Postdoctoral Fellow, Department of Stem Cell Biology, FAU Erlangen-Nürnberg

Research focus

Motor neuron diseases comprise a heterogeneous group of neurodegenerative diseases leading to progressive disability. Focusing on amyotrophic lateral sclerosis and hereditary spastic paraplegia, I aim to improve the understanding of the molecular basis of these diseases. To this end, I use patient-derived induced pluripotent stem cells (iPS) and the respective derived neuronal subtypes are analyzed on the cellular and molecular level.

Publications

Pozner T*, Regensburger M*, Engelhorn T, Winkler J, Winner B (2020) Janus-faced spatacsin (SPG11): involvement in neurodevelopment and multisystem neurodegeneration. Brain. BRAIN-2019-01856.R1. *equal contribution

Regensburger M (2020) Which kinds of fasciculations are missed by ultrasonography in ALS? Clin Neurophysiol 131: 237-238. doi: 10.1016/j.clinph.2019.09.011

Regensburger M, Minakaki G, Kettwig M, Eisenhut F, Haack T, Kohl Z, Winkler J (2020) Novel biallelic CTSD gene variants cause late-onset ataxia and retinitis pigmentosa. Movement Disorders. Mov. Disord. 2020 May 18. doi: 10.1002/mds.28106. Online ahead of print.

Pozner T*, Schray A*, Regensburger M, Lie DC, Schlötzer-Schrehardt U, Winkler J, Turan S, Winner B (2018) Tideglusib Rescues Neurite Pathology of SPG11 iPSC Derived Cortical Neurons. Front Neurosci 2018 Dec 6;12:43. doi: 10.3389/fnins.2018.00914.s001 *equal contribution

Pérez-Brangulí F*, Buchsbaum IY*, Pozner T*, Regensburger M, Fan W, Schray A, Börstler T, Mishra H, Gräf D, Kohl Z, Winkler J, Berninger B, Cappello S, Winner B (2018) Human SPG11 cerebral organoids reveal cortical neurogenesis impairment. Hum Mol Genet 2018 Nov 22. doi: 10.1093/hmg/ddy397 *equal contribution

Popp B, Krumbiegel M, Grosch J, Sommer A, Uebe S, Kohl Z, Plötz S, Farrell M, Trautmann U, Kraus C, Ekici, AB, Asadollahi R, Regensburger M, Günther K, Rauch A, Edenhofer F, Winkler J, Winner B, Reis A (2018) Need for high-resolution Genetic Analysis in iPSC: Results and Lessons from the ForIPS Consortium. Sci Rep 8, 17201. doi:10.1038/s41598-018-35506-0

Regensburger M, Weidner N, Kohl Z (2018). Motor neuron disease – clinical and genetic differential diagnosis. Nervenarzt, 89, 658–665. doi:10.1038/nn.4000.

Regensburger M, Mielenz D, Winner B (2018). Swiprosin-1/EFhd2 – another piece in the puzzle of tauopathy? Aging. doi:10.18632/aging.101431. Editorial.

Regensburger M, Prots I, Reimer D, Brachs S, Loskarn S, Lie DC, Mielenz D, Winner B (2018) Impact of Swiprosin-1/EFhd2 on adult hippocampal neurogenesis. Stem Cell Rep 10(2):347-355.

Regensburger M, Tenner F, Möbius C, Schramm A (2018) Detection radius of EMG for fasciculations: empiric study combining ultrasonography and electromyography. Clin Neurophysiol 129:487-493. doi: 10.1016/j.clinph.2017.10.037

Regensburger M, Schreglmann SR, Stoll S, Rockenstein E, Loskarn S, Wei Xiang, Masliah E, Winner B (2018) Oligomer-prone E57K- mutant alpha-synuclein exacerbates integration deficit of adult hippocampal newborn neurons in transgenic mice. Brain Struct Funct 223(3):1357-1368.

Schneider-Gold C, Dekomien G, Regensburger M, Schneider R, Trampe N, Krogias C, Lukas C, Bellenberg B (2017). Monozygotic twins with a new compound heterozygous SPG11 mutation and different disease expression. J Neurol Sci 381:265-268. doi: 10.1016/j.jns.2017.09.005

Regensburger M, Türk M, Pagenstecher A, Schröder R, Winkler J (2017). VCP-related multisystem-proteinopathy presenting as early-onset Parkinson’s disease. Neurology 89(7):746–8. doi: 10.1212/WNL.0000000000004240

Tenner F*, Regensburger M*, Schramm A, Söhle M, Schwarzkopf K, Zalevsky Z, Schmidt M (2017). Evaluation of a Laser-Based Sensor for the Diagnosis of Neurological Disorders. Conf Proc IEEE Eng Med Biol Soc 2017:4231–4. *contributed equally

Schreglmann SR, Regensburger M, Rockenstein E, Masliah E, Xiang W, Winkler J, Winner B (2015) The temporal expression pattern of alpha-Synuclein modulates olfactory neurogenesis in transgenic mice. PLoS One 10(5):e0126261.

Madzar D, Hagge M, Möller S, Regensburger M, Lee DH, Schwab S, Jantsch J (2015).Endogenous endophthalmitis complicating Streptococcus equi subspecies zooepidemicus meningitis: a case report. BMC Res Notes 8:184. doi: 10.1186/s13104-015-1133-9

Regensburger M, Huttner HB, Doerfler A, Schwab S, Staykov D (2014). Propofol-related urine discoloration in a patient with fatal atypical intracerebral hemorrhage treated with hypothermia. Springerplus 3:551. doi: 10.1186/2193-1801-3-551

Purohit P, Perez-Branguli F, Prots I, Borger E, Gunn-Moore F, Welzel O, Loy K, Wenzel E, Grömer TW, Brachs S, Holzer M, Buslei R, Fritsch K, Regensburger M, Böhm KJ, Winner B, Mielenz D (2014) The Ca2+ sensor protein Swiprosin-1/EFhd2 is a synaptic protein and involved in kinesin-mediated axonal transport in neurons. PLoS One 18;9(8):e103976.

Pérez-Brangulí F, Mishra HK, Prots I, Havlicek S, Kohl Z, Saul D, Rummel C, Dorca-Arevalo J, Regensburger M, Graef D, Sock E, Blasi J, Groemer TW, Schlötzer-Schrehardt U, Winkler J, Winner B (2014) Dysfunction of spatacsin leads to axonal pathology in SPG11-linked hereditary spastic paraplegia. Hum Mol Genet 23(18):4859-74.

Schlachetzki JCM, Marxreiter F, Regensburger M, Kulinich A, Winner B, Winkler J (2014) Increased tyrosine hydroxylase expression accompanied by glial changes within the non-lesioned hemisphere in the 6-hydroxydopamine model of Parkinson’s disease. Restor Neurol Neurosci 32(4):447-62.

Regensburger M, Prots I, Winner B (2014). Adult hippocampal neurogenesis in Parkinson’s disease: impact on neuronal survival and plasticity. Neural Plast 2014:454696. doi: 10.1155/2014/454696. Review.

Marxreiter F, Regensburger M, Winkler J (2013). Adult neurogenesis in Parkinson’s disease. Cell Mol Life Sci. 2013 Feb;70(3):459-73. doi: 10.1007/s00018-012-1062-x. Review.

Winner B*, Regensburger M*, Schreglmann S. Boyer L, Prots I, Rockenstein E, ManteM, Zhao C, Winkler J, Masliah E, Gage FH (2012) Role of α-synuclein in adult neurogenesis and neuronal maturation in the dentate gyrus. J Neurosci 32(47):16906-16; *contributed equally

Kohl Z, Regensburger M, Aigner R, Kandasamy M, Winner B, Aigner L, Winkler J (2010) Impaired adult olfactory bulb neurogenesis in the R6/2 mouse model of Huntington’s disease. BMC Neurosci 13;11:114.

Regensburger M, Kohl Z, Grundmann K, Winner B, Riess O, Winkler J (2009) Adult neurogenesis in transgenic animal models of DYT1 dystonia. Neuroreport 20(17):1529-33.

Dr. Patrick Süß

Clinician Scientist, MD rotation position 2019

Department for Molecular Neurology
Prof. Jürgen Winkler

2017 Resident, Institute of Neuropathology, University of Freiburg

2018 MD, FAU Erlangen-Nürnberg

2018 Resident, Department of Psychiatry and Psychotherapy, University of Freiburg

2019 Resident and Postdoctoral fellow, Department of Molecular Neurology, FAU Erlangen-Nürnberg

Research focus

Microglia are the brain-resident myeloid cells and the main effector cells of the innate immune system in the central nervous system (CNS). Together with other myeloid cell populations, they substantially influence CNS functions under homeostasis as well as in neuroinflammatory and neurodegenerative disorders. Moreover, CNS myeloid cells dynamically respond to peripheral inflammatory challenges.

My research focuses on the influence of the peripheral immune system on CNS myeloid cells in health and disease. By using animal models of both inflammatory diseases like rheumatoid arthritis (RA) and neurodegenerative diseases, I aim to elucidate spatiotemporal differences in the vulnerability of the CNS towards peripheral inflammation and develop treatment approaches targeting CNS myeloid cells from the periphery.

Publications

Original articles

Süß P*, Hoffmann A*, Rothe T*, Ouyang Z, Baum W, Staszewski O, Schett G, Prinz M, Krönke G, Glass CK, Winkler J, Schlachetzki JCM. Chronic peripheral inflammation causes a region-specific myeloid response in the central nervous system (2020). Cell Rep. *equal contribution

Shemer A, Grozovski J, Tay TL, Tao J, Volaski A, Süß P, Ardura-Fabregat A, Gross-Vered M, Kim JS, David E, Chappell-Maor L, Thielecke L, Glass CK, Cornils K, Prinz M, Jung S (2018). Engrafted parenchymal brain macrophages differ from microglia in transcriptome, chromatin landscape and response to challenge. Nat Commun 9, 5206.

Süß P, Kalinichenko L, Baum W, Reichel M, Kornhuber J, Loskarn S, Ettle B, Distler JH, Schett G, Winkler J, Müller CP, Schlachetzki JC (2015). Hippocampal structure and function are maintained despite severe innate peripheral inflammation. Brain Behav Immun 49, 156-170.

 

Reviews and comments

Süß P, Schlachetzki JCM. Microglia in Alheimer’s Disease (2020). Curr Alzheimer Res. doi: 10.2174/1567205017666200212155234.

Süß P (2017). Remote Control: Impacts of Peripheral Tumor Necrosis Factor-Alpha on Alzheimer Disease-Related Pathology. J Neurosci 37, 8045-8047.

 

Case Reports

Endres D, Pruss H, Rauer S, Süß P, Venhoff N, Feige B, Schweizer T, Nickel K, Maier S, Egger K, Domschke K, Meyer PT, Tebartz van Elst L (2020) Probable Autoimmune Catatonia With Antibodies Against Cilia on Hippocampal Granule Cells and Highly Suspicious Cerebral FDG-Positron Emission Tomography Findings. Biol Psychiatry 87: e29-e31. doi: 10.1016/j.biopsych.2019.12.020

Endres D, Rauer S, Kern W, Venhoff N, Maier SJ, Runge K, Süß P, Feige B, Nickel K, Heidt T, Domschke K, Egger K, Prüss H, Meyer PT, Tebartz van Elst L (2019). Psychiatric Presentation of Anti-NMDA Receptor Encephalitis. Front Neurol 10, 1086.

Lüngen EM, Maier V, Venhoff N, Salzer U, Dersch R, Berger B, Riering AN, Nickel K, Fiebich BL, Süß P, Maier SJ, Egger K, Tebartz van Elst L, Endres D (2019). Systemic Lupus Erythematosus With Isolated Psychiatric Symptoms and Antinuclear Antibody Detection in the Cerebrospinal Fluid. Front Psychiatry 10, 226.

Endres D, Süß P, Maier SJ, Friedel E, Nickel K, Ziegler C, Fiebich BL, Glocker FX, Stock F, Lange T, Dacko M, Venhoff N, Erny D, Doostkam S, Komlosi K, Domschke K, Tebartz van Est L (2019). New variant of MELAS Syndrome with Executive Dysfunction, Heteroplasmic Point Mutation in the MT-ND4 Gene (m.12015T>C; p.Leu419Pro) and comorbid polyglandular Autoimmune Syndrome Type 2. Front Immunol 10, 412.

Süß P, Volz F, Lang C, Staszewksi O, Palmedo G, Taschner CA, Scheiwe C, Kurz P, Mentzel T, Prinz M (2018). A Case of Large Meningeal Epithelioid Hemangioendothelioma With WWTR1-CAMTA1 Gene Rearrangement and Slow Growth Over 15 Years. J Neuropathol Exp Neurol 77, 871-876.

Rauer S, Stork L, Urbach H, Stathi A, Marx A, Süß P, Prinz M, Brück W, Metz I (2018). Drug reaction with eosinophilia and systemic symptoms after daclizumab therapy. Neurology 91, e359-e363.

Taschner CA, Süß P, Volz F, Urbach H, Dovi-Akué P, Prinz M (2018). Freiburg Neuropathology Case Conference: A Painless Mass Lesion of the Parietal and Occipital Bones. Clin Neuroradiol 28, 301-306.

Taschner CA, Süß P, Hohenhaus M, Urbach H, Lützen N, Prinz M (2018). Freiburg Neuropathology Case Conference: Tumor Located in the Anterior Portion of the Third Ventricle. Clin Neuroradiol 28,139-143.

Taschner CA, Süß P, Sajonz B, Urbach H, Simon-Gabriel CP, Prinz M (2017). Freiburg Neuropathology Case Conference: Widespread White Matter Lesions in a Patient with Progressive Paraparesis and Cortical Blindness. Clin Neuroradiol 27, 245-250.