- Job title: Research Fellow
- Organization: Institute of Biochemistry
- Working group: Professorship of Molecular Medicine with focus in Molecular Imaging
- Phone number: +49 9131 8524146
- Email: email@example.com
- Website: http://www.biochem.fau.de/forschung/arbeitsgruppe.php?arbeitsgruppe=5
2003 Diploma in Biology, University of Münster
2007 PhD, University of Mainz
2008 Postdoctoral Fellow, Helmholtz Centre Munich
2013 Senior Research Fellow, FAU
Interaction of stem cells and their progeny with their microenvironment is critical for regulation of hippocampal neurogenesis. Astrocytes are considered major components of the hippocampal neurogenic niche, but their specific contribution to neurogenesis-dependent plasticity remains largely understudied. In contrast to the prevailing assumption that mature astrocytes are postmitotic in the non-injured adult brain, I recently identified astrocyte subtypes, which started to proliferate in response to pro- or anti-neurogenic stimuli, thus revealing unexpected astrocyte plasticity. In my research I pursue the novel hypothesis that astrocyte heterogeneity and astrogenesis are critical modulators of neurogenesis-dependent plasticity.
2008 Diploma degree in Biology, FAU Erlangen-Nürnberg
2008 Graduate student, FAU Erlangen-Nürnberg
2012 Postdoctoral fellow, FAU Erlangen-Nürnberg
My research focuses on the identification and functional analysis of novel regulators and modifiers of glial development and myelination in vitro and in vivo. To obtain a better understanding of transcriptional regulatory networks, which jointly work together during glial development to enable proper myelination and remyelination, I focus on potential targets and interactors of known key regulators of myelination processes, such as the transcription factors Sox10 and Myrf in oligodendrocytes.
2001 Diploma in Biochemistry, Leipzig University
2001 PhD student at the Friedrich-Alexander University of Erlangen-Nuernberg (FAU)
2007 Research Assistant at the Medical University of Innsbruck (MUI)
2008 Postdoctoral Fellow at the University Hospital Erlangen / FAU
Recent data strongly indicate the influence of the sphingolipid metabolism in the pathophysiology of neuropsychiatric diseases such as depression, alcohol addiction and neurodegeneration. We characterize the involved sphingomyelinase and ceramidase enzymes in various biological materials and investigate their genetic variation, activity and regulation in animal / cell culture models, healthy individuals and patients. Thereby we aim to better understand the underlying molecular mechanisms as well as to evaluate the suitability of these enzymes as diagnostic or prognostic biomarkers and as preventive and therapeutic targets.
2011 MD, University of Regensburg
2012 M.Sc. (Neurosciences), University of Regensburg
since 2011 Resident, Department of Neurology and Postdoctoral Fellow, Department of Stem Cell Biology, FAU Erlangen-Nürnberg
Motor neuron diseases comprise a heterogeneous group of neurodegenerative diseases leading to progressive disability. Focusing on amyotrophic lateral sclerosis and hereditary spastic paraplegia, I aim to improve the understanding of the molecular basis of these diseases. To this end, I use patient-derived induced pluripotent stem cells (iPS) and the respective derived neuronal subtypes are analyzed on the cellular and molecular level.
2007 Diploma in Molecular Medicine, FAU Erlangen-Nürnberg
2010 PhD, FAU Erlangen-Nürnberg
2010 Postdoctoral Fellow, FAU Erlangen-Nürnberg
Myelination and accordingly the development of myelin-forming glial cells is a central process during embryogenesis and regeneration of the nervous system. My research focuses on the transcriptional control of gliogenesis and its modulation by microRNAs. Technical approaches include animal models and primary cell culture as well as molecular biochemistry.
2007 Diploma in Biology TU Braunschweig
2011 Dr. rer. nat, Medical School Hannover
2011- 2013 Postdoctoral Fellow, Medical School Hannover
2013- 2015 Postdoctoral Fellow, Stanford University
2016 Postdoctoral Fellow, FAU Erlangen
Sox11 is a member of the group C SOX transcription factor family and is a critical transcriptional regulator of embryonic and adult neurogenesis. It was shown that heterozygous de novo mutations in Sox11 or deletions of Sox11 cause Coffin-Siris syndrome (CSS), a rare monogenic disease characterized by hypoplastic nails, microcephaly, and mental retardation. I am interested in developing and testing genetically engineered in vitro models to understand the role of Sox11 in human neurodevelopmental diseases.