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Postdoctoral Researchers

Associated Researchers

Dr. Ruth Beckervordersandforth

2003 Diploma in Biology, University of Münster

2007 PhD, University of Mainz

2008 Postdoctoral Fellow, Helmholtz Centre Munich

2013 Senior Research Fellow, FAU

Research focus

Interaction of stem cells and their progeny with their microenvironment is critical for regulation of hippocampal neurogenesis. Astrocytes are considered major components of the hippocampal neurogenic niche, but their specific contribution to neurogenesis-dependent plasticity remains largely understudied. In contrast to the prevailing assumption that mature astrocytes are postmitotic in the non-injured adult brain, I recently identified astrocyte subtypes, which started to proliferate in response to pro- or anti-neurogenic stimuli, thus revealing unexpected astrocyte plasticity. In my research I pursue the novel hypothesis that astrocyte heterogeneity and astrogenesis are critical modulators of neurogenesis-dependent plasticity.

Dr. Melanie Küspert

2008 Diploma degree in Biology, FAU Erlangen-Nürnberg

2008 Graduate student, FAU Erlangen-Nürnberg

2012 Postdoctoral fellow, FAU Erlangen-Nürnberg

Research focus

My research focuses on the identification and functional analysis of novel regulators and modifiers of glial development and myelination in vitro and in vivo. To obtain a better understanding of transcriptional regulatory networks, which jointly work together during glial development to enable proper myelination and remyelination, I focus on potential targets and interactors of known key regulators of myelination processes, such as the transcription factors Sox10 and Myrf in oligodendrocytes.

Publications

Cantone M* & Küspert M* & Reiprich S*, Lai X, Eberhardt M, Göttle P, Beyer F, Azim K, Küry P, Wegner M & Vera J (2018) A gene regulatory architecture that controls regionindependent dynamics of oligodendrocyte differentiation. Glia. Accepted for publication. (*authors contributed equally to this publication)

Jacob A & Wüst HM, Thalhammer JM, Fröb F, Küspert M, Reiprich S, Balta E-A, Lie DC, Wegner M, Sock E (2018) The homeodomain transcription factor Prox1 is a direct target of SoxC proteins during developmental vertebrate neurogenesis. Journal of Neurochemistry 146(3):251-268.

Weider M & Starost LJ & Groll K, Küspert M, Sock E, Wedel M, Fröb F, Schmitt C, Baroti T, Hartwig AC, Hillgärtner S, Piefke S, Fadler T, Ehrlich M, Ehlert C, Stehling M, Albrecht S, Jabali A, Schöler HR, Winkler J, Kuhlmann T, Wegner M. (2018) Nfat/calcineurin signaling promotes oligodendrocyte differentiation and myelination by transcription factor network tuning. Nature Communications 9(1):899.

Reiprich S & Cantone M & Weider M, Baroti T, Wittstatt J, Schmitt C, Küspert M, Vera J, Wegner M (2017) Transcription factor Sox10 regulates oligodendroglial Sox9 levels via microRNAs. Glia 65(7):1089-1102.

Wegener A, Küspert M, Sock E, Philipsen S, Suske G, Wegner M (2017) Sp2 is the only glutamine-rich specificity protein with minor impact on development and differentiation in myelinating glia. Journal of Neurochemistry 140(2):245-256.

Mehta P, Küspert M, Bale T, Brownstein CA, Towne MC, De Girolami U, Shi J, Beggs AH, Darras BT, Wegner M, Piao X, Agrawal PB (2017) Novel Mutation in CNTNAP1 results in Congenital Hypomyelinating Neuropathy. Muscle & Nerve 55(5):761-765.

Muth KN, Piefke S, Weider M, Sock E, Hermans-Borgmeyer I, Wegner M, Küspert M (2016) The Dual-specificity phosphatase Dusp15 is regulated by Sox10 and Myrf in Myelinating Oligodendrocytes. Glia 64(12):2120-2132.

Küspert M, Wegner M (2016) SomethiNG 2 talk about-Transcriptional regulation in embryonic and adult oligodendrocyte precursors. Brain Research 1638(Pt B):167-182. Review

Weider M & Wegener A, Schmitt C, Küspert M, Hillgärtner S, Bösl MR, Hermans-Borgmeyer I, Nait-Oumesmar B, Wegner M (2015) Elevated In Vivo Levels of a Single Transcription Factor Directly Convert Satellite Glia into Oligodendrocyte-like Cells. PLoS Genetics 11(2) e1005008.

Bischof M, Weider M, Küspert M, Nave KA, Wegner M (2015) Brg1-dependent Chromatin remodelling is not essentially required during oligodendroglial differentiation. Journal of Neuroscience 35(1):21-35.

Hoffmann S, Hos D, Küspert M, Lang RA, Lovell-Badge R, Wegner M, Reiprich S (2014) Stem cell factor Sox2 and its close relative Sox3 have differentiation functions in oligodendrocytes. Development 141(1):39-50.

Vogl MR, Reiprich S, Küspert M, Kosian T, Schrewe H, Nave KA, Wegner M (2013) Sox10 Cooperates with the Mediator Subunit 12 during Terminal Differentiation of Myelinating Glia. Journal of Neuroscience 33(15):6679-6690.

Weider M* & Küspert M*, Bischof M, Vogl MR, Hornig J, Loy K, Kosian T, Müller J, Hillgärtner S, Tamm ER, Metzger D, Wegner M (2012) Chromatin-Remodeling Factor Brg1 Is Required for Schwann Cell Differentiation and Myelination. Developmental Cell 23(1):193-201.(*authors contributed equally to this publication)

Küspert M, Weider M, Müller J, Hermans-Borgmeyer I, Meijer D, Wegner M (2012) Desert hedgehog links transcription factor Sox10 to perineurial development. Journal of Neuroscience 32(16):5472-5480.

Küspert M, Hammer A, Bösl MR, Wegner M (2011) Olig2 regulates Sox10 expression in oligodendrocyte precursors through an evolutionary conserved distal enhancer. Nucleic Acids Research 39(4):1280-1293.

Walter B, Küspert M, Ansorge D, Krämer R, Burkovski A (2008) Dissection of Ammonium uptake systems in Corynebacterium glutamicum: mechanism of action and energetics ofAmtA and AmtB. Journal of Bacteriology 190(7):2611-2614.

 

Dr. Christiane Mühle

2001 Diploma in Biochemistry, Leipzig University

2001 PhD student at the Friedrich-Alexander University of Erlangen-Nuernberg (FAU)

2007 Research Assistant at the Medical University of Innsbruck (MUI)

2008 Postdoctoral Fellow at the University Hospital Erlangen / FAU

Research focus

Recent data strongly indicate the influence of the sphingolipid metabolism in the pathophysiology of neuropsychiatric diseases such as depression, alcohol addiction and neurodegeneration. We characterize the involved sphingomyelinase and ceramidase enzymes in various biological materials and investigate their genetic variation, activity and regulation in animal / cell culture models, healthy individuals and patients. Thereby we aim to better understand the underlying molecular mechanisms as well as to evaluate the suitability of these enzymes as diagnostic or prognostic biomarkers and as preventive and therapeutic targets.

Dr. Martin Regensburger

 

2011 MD, University of Regensburg

2012 M.Sc. (Neurosciences), University of Regensburg

since 2011 Resident, Department of Neurology and Postdoctoral Fellow, Department of Stem Cell Biology, FAU Erlangen-Nürnberg

Research focus

Motor neuron diseases comprise a heterogeneous group of neurodegenerative diseases leading to progressive disability. Focusing on amyotrophic lateral sclerosis and hereditary spastic paraplegia, I aim to improve the understanding of the molecular basis of these diseases. To this end, I use patient-derived induced pluripotent stem cells (iPS) and the respective derived neuronal subtypes are analyzed on the cellular and molecular level.

Publications

Pozner T, Schray A, Regensburger M, Lie DC, Schlötzer-Schrehardt U, Winkler J, Turan S, Winner B (2018) Tideglusib Rescues Neurite Pathology of SPG11 iPSC Derived Cortical Neurons. Front Neurosci 2018 Dec 6;12:43. doi: 10.3389/fnins.2018.00914.s001

Pérez-Brangulí F, Buchsbaum IY, Pozner T, Regensburger M, Fan W, Schray A, Börstler T, Mishra H, Gräf D, Kohl Z, Winkler J, Berninger B, Cappello S, Winner B (2018) Human SPG11 cerebral organoids reveal cortical neurogenesis impairment. Hum Mol Genet 2018 Nov 22. doi: 10.1093/hmg/ddy397

Popp B, Krumbiegel M, Grosch J, Sommer A, Uebe S, Kohl Z, Plötz S, Farrell M, Trautmann U, Kraus C, Ekici, AB, Asadollahi R, Regensburger M, Günther K, Rauch A, Edenhofer F, Winkler J, Winner B, Reis A (2018) Need for high-resolution Genetic Analysis in iPSC: Results and Lessons from the ForIPS Consortium. Sci Rep 8, 17201. doi:10.1038/s41598-018-35506-0

 Regensburger M, Weidner N, Kohl Z (2018). Motor neuron disease – clinical and genetic differential diagnosis. Nervenarzt, 89, 658–665. doi:10.1038/nn.4000.

Regensburger M, Mielenz D, Winner B (2018). Swiprosin-1/EFhd2 – another piece in the puzzle of tauopathy? Aging. doi:10.18632/aging.101431. Editorial.

Regensburger M, Prots I, Reimer D, Brachs S, Loskarn S, Lie DC, Mielenz D, Winner B (2018) Impact of Swiprosin-1/EFhd2 on adult hippocampal neurogenesis. Stem Cell Rep 10(2):347-355.

 Regensburger M, Tenner F, Möbius C, Schramm A (2018) Detection radius of EMG for fasciculations: empiric study combining ultrasonography and electromyography. Clin Neurophysiol 129:487-493. doi: 10.1016/j.clinph.2017.10.037

Regensburger M, Schreglmann SR, Stoll S, Rockenstein E, Loskarn S, Wei Xiang, Masliah E, Winner B (2018) Oligomer-prone E57K- mutant alpha-synuclein exacerbates integration deficit of adult hippocampal newborn neurons in transgenic mice. Brain Struct Funct 223(3):1357-1368.

Schneider-Gold C, Dekomien G, Regensburger M, Schneider R, Trampe N, Krogias C, Lukas C, Bellenberg B (2017). Monozygotic twins with a new compound heterozygous SPG11 mutation and different disease expression. J Neurol Sci 381:265-268. doi: 10.1016/j.jns.2017.09.005

Regensburger M, Türk M, Pagenstecher A, Schröder R, Winkler J (2017). VCP-related multisystem-proteinopathy presenting as early-onset Parkinson’s disease. Neurology 89(7):746–8. doi: 10.1212/WNL.0000000000004240

Tenner F*, Regensburger M*, Schramm A, Söhle M, Schwarzkopf K, Zalevsky Z, Schmidt M (2017). Evaluation of a Laser-Based Sensor for the Diagnosis of Neurological Disorders. Conf Proc IEEE Eng Med Biol Soc 2017:4231–4. *contributed equally

Schreglmann SR, Regensburger M, Rockenstein E, Masliah E, Xiang W, Winkler J, Winner B (2015) The temporal expression pattern of alpha-Synuclein modulates olfactory neurogenesis in transgenic mice. PLoS One 10(5):e0126261.

Madzar D, Hagge M, Möller S, Regensburger M, Lee DH, Schwab S, Jantsch J (2015).Endogenous endophthalmitis complicating Streptococcus equi subspecies zooepidemicus meningitis: a case report. BMC Res Notes 8:184. doi: 10.1186/s13104-015-1133-9

Regensburger M, Huttner HB, Doerfler A, Schwab S, Staykov D (2014). Propofol-related urine discoloration in a patient with fatal atypical intracerebral hemorrhage treated with hypothermia. Springerplus 3:551. doi: 10.1186/2193-1801-3-551

Purohit P, Perez-Branguli F, Prots I, Borger E, Gunn-Moore F, Welzel O, Loy K, Wenzel E, Grömer TW, Brachs S, Holzer M, Buslei R, Fritsch K, Regensburger M, Böhm KJ, Winner B, Mielenz D (2014) The Ca2+ sensor protein Swiprosin-1/EFhd2 is a synaptic protein and involved in kinesin-mediated axonal transport in neurons. PLoS One 18;9(8):e103976.

Pérez-Brangulí F, Mishra HK, Prots I, Havlicek S, Kohl Z, Saul D, Rummel C, Dorca-Arevalo J, Regensburger M, Graef D, Sock E, Blasi J, Groemer TW, Schlötzer-Schrehardt U, Winkler J, Winner B (2014) Dysfunction of spatacsin leads to axonal pathology in SPG11-linked hereditary spastic paraplegia. Hum Mol Genet 23(18):4859-74.

Schlachetzki JCM, Marxreiter F, Regensburger M, Kulinich A, Winner B, Winkler J (2014)  Increased tyrosine hydroxylase expression accompanied by glial changes within the non-lesioned hemisphere in the 6-hydroxydopamine model of Parkinson’s disease. Restor Neurol Neurosci 32(4):447-62.

Regensburger M, Prots I, Winner B (2014). Adult hippocampal neurogenesis in Parkinson’s disease: impact on neuronal survival and plasticity. Neural Plast 2014:454696. doi: 10.1155/2014/454696. Review.

Marxreiter F, Regensburger M, Winkler J (2013). Adult neurogenesis in Parkinson’s disease. Cell Mol Life Sci. 2013 Feb;70(3):459-73. doi: 10.1007/s00018-012-1062-x. Review.

Winner B*, Regensburger M*, Schreglmann S. Boyer L, Prots I, Rockenstein E, ManteM, Zhao C, Winkler J, Masliah E, Gage FH (2012) Role of α-synuclein in adult neurogenesis and neuronal maturation in the dentate gyrus. J Neurosci 32(47):16906-16; *contributed equally

Kohl Z, Regensburger M, Aigner R, Kandasamy M, Winner B, Aigner L, Winkler J (2010) Impaired adult olfactory bulb neurogenesis in the R6/2 mouse model of Huntington’s disease. BMC Neurosci 13;11:114.

Regensburger M, Kohl Z, Grundmann K, Winner B, Riess O, Winkler J (2009) Adult neurogenesis in transgenic animal models of DYT1 dystonia. Neuroreport 20(17):1529-33.

Dr. Simone Reiprich

2007 Diploma in Molecular Medicine, FAU Erlangen-Nürnberg

2010 PhD, FAU Erlangen-Nürnberg

2010 Postdoctoral Fellow, FAU Erlangen-Nürnberg

Research focus

Myelination and accordingly the development of myelin-forming glial cells is a central process during embryogenesis and regeneration of the nervous system. My research focuses on the transcriptional control of gliogenesis and its modulation by micro-RNAs. Technical approaches include animal models and primary cell culture as well as molecular biochemistry.

Dr. Sören Turan

2007 Diploma in Biology TU Braunschweig

2011 Dr. rer. nat, Medical School Hannover

2011- 2013 Postdoctoral Fellow, Medical School Hannover

2013- 2015 Postdoctoral Fellow, Stanford University

2016 Postdoctoral Fellow, FAU Erlangen

Research focus

Sox11 is a member of the group C SOX transcription factor family and is a critical transcriptional regulator of embryonic and adult neurogenesis. It was shown that heterozygous de novo mutations in Sox11 or deletions of Sox11 cause Coffin-Siris syndrome (CSS), a rare monogenic disease characterized by hypoplastic nails, microcephaly, and mental retardation. I am interested in developing and testing genetically engineered in vitro models to understand the role of Sox11 in human neurodevelopmental diseases.

Publications

Pozner, T*, Schray, A*, Regensburger, M, Lie, D.C., Schlötzer-Schrehardt, U, Winkler, J, Turan, S., Winner, B. Tideglusib Rescues Neurite Pathology of SPG11 iPSC Derived Cortical Neurons. Front Neurosci. (2018); 12:914. doi: 10.3389/fnins.2018.00914. *contributed equally

Kavyanifar, A.*, Turan, S.* & Lie, D.C. SoxC transcription factors: multifunctional regulators of neurodevelopment. Cell Tissue Res (2018) 371: 91. http://doi.org/10.1007/s00441-017-2708-7. *contributed equally

Turan, S., Farruggio, A. P., Srifa, W., Day, J. W., & Calos, M. P. Precise correction of disease mutations in induced pluripotent stem cells derived from patients with limb girdle muscular dystrophy. Molecular Therapy (2016) 24:4, 685-696

Geisinger, J. M., Turan, S., Hernandez, S., Spector, L. P., & Calos, M. P. In Vivo Blunt-End Cloning Through CRISPR / Cas9-Facilitated Non-Homologous end-joining. Nucl. Acids Res., (2016) 44:8,doi:10.1093/nar/gkv1542

Mayrhofer, P., Kratzer, B., Sommeregger, W., Steinfellner, W., Reinhart, D., Mader, A., Turan, S. … Kunert, R. Accurate comparison of antibody expression levels by reproducible transgene targeting in engineered recombination-competent CHO cells. Applied Microbiology and Biotechnology (2014), doi:10.1007/s00253-014-6011-1

Turan, S., Qiao, J., Madden, S., Benham, C., Kotz, M., Schambach, A., and Bode, J. Expanding Flp-RMCE options: the potential of Recombinase Mediated Twin-Site Targeting (RMTT). Gene. (2014) doi:10.1016/j.gene.2014.06.002

Kuehle, J.*, Turan, S.*, Cantz, T., Hoffmann, D., Suerth, J. D., Maetzig, T., … Schambach, A. Modified lentiviral LTRs allow Flp recombinase-mediated cassette exchange and in vivo tracing of “factor-free” induced pluripotent stem cells. Molecular Therapy, (2014) 22:5, 919–28. doi:10.1038/mt.2014.4 *contributed equally

Maetzig, T., Kuehle, J., Schwarzer, A., Turan, S., Rothe, M., Chaturvedi, A., … Schambach, A. All-in-One inducible lentiviral vector systems based on drug controlled FLP recombinase. Biomaterials, (2014) 35:14, 4345–56. doi:10.1016/j.biomaterials.2014.01.057

Turan, S., Zehe, C., Kuehle, J., Qiao, J., and Bode, J. Recombinase-mediated cassette exchange (RMCE) – a rapidly-expanding toolbox for targeted genomic modifications. Gene, (2013) 515(1), 1–27. doi:10.1016/j.gene.2012.11.016

Turan, S., and Bode, J. Site-specific recombinases: from tag-and-target- to tag-and-exchange-based genomic modifications. FASEB J. (2013) 25:4088-4107; doi:10.1096/fj.11-186940

Turan, S., Galla, M., Ernst, E., Qiao, J., Voelkel, C., Schiedlmeier, B., Zehe, C. and Bode, J. Recombinase-mediated cassette exchange (RMCE): traditional concepts and current challenges, Journal of Molecular Biology, (2011) 407(2):193-221

Turan, S., Kuehle, J., Schambach, A., Baum, C., Bode, J. Multiplexing RMCE: Versatile Extensions ofthe Flp-Recombinase-Mediated Cassette-Exchange Technology, Journal of Molecular Biology, (2010) 402:52-69, ISSN 0022-2836