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Original articles (peer-reviewed)

  1. Allison R, Edgar JR, Pearson G, Rizo T, Newton T, Gunther S, Berner F, Hague J, Connell JW, Winkler J, Lippincott-Schwartz J, Beetz C, Winner B, Reid E (2017) Defects in ER-endosome contacts impact lysosome function in hereditary spastic paraplegia. J Cell Biol 216: 1337-1355. doi: 10.1083/jcb.201609033
  2. Aprato J, Sock E, Weider M, Elsesser O, Fröb F, Wegner M (2020) Myrf guides target gene selection of transcription factor Sox10 during oligodendroglial development. Nucleic Acids Res 48: 1254-1270. doi: 10.1093/nar/gkz1158
  3. Balta EA, Schäffner I, Wittmann MT, Sock E, von Zweydorf F, von Wittgenstein J, Steib K, Heim B, Kremmer E, Häberle BM, Ueffing M, Lie DC, Gloeckner CJ (2018) Phosphorylation of the neurogenic transcription factor SOX11 on serine 133 modulates neuronal morphogenesis. Sci Rep 8: 16196. doi: 10.1038/s41598-018-34480-x
  4. Balta EA, Wittmann MT, Jung M, Sock E, Häberle BM, Heim B, von Zweydorf F, Heppt J, von Wittgenstein J, Gloeckner CJ, Lie DC (2018) Phosphorylation Modulates the Subcellular Localization of SOX11. Front Mol Neurosci 11: 211. doi: 10.3389/fnmol.2018.00211
  5. Beckervordersandforth R*, Ebert B*, Schäffner I, Moss J, Fiebig C, Shin J, Moore DL, Ghosh L, Trinchero MF, Stockburger C, Friedland K, Steib K, von Wittgenstein J, Keiner S, Redecker C, Holter SM, Xiang W, Wurst W, Jagasia R, Schinder AF, Ming GL, Toni N, Jessberger S, Song HJ, Lie DC (2017) Role of Mitochondrial Metabolism in the Control of Early Lineage Progression and Aging Phenotypes in Adult Hippocampal Neurogenesis. Neuron 93(3):560-573. doi: 10.1016/j.neuron.2017.03.008
  6. Bouna-Pyrrou P, Aufleger B, Braun S, Gattnar M, Kallmayer S, Wagner H, Kornhuber J, Mühle C*, Lenz B* (2018) Cross-Sectional and Longitudinal Evaluation of the Social Network Use Disorder and Internet Gaming Disorder Criteria. Frontiers in Psychiatry 9:692. doi: 10.3389/fpsyt.2018.00692
  7. Brazdis RM, Alecu J, Marsch D, Dahms A, Simmnacher K, Lorentz S, Brendler A, Schneider Y, Marxreiter F, Roybon L, Winner B, Xiang W, Prots I (2020) Demonstration of brain region-specific neuronal vulnerability in human iPSC-based model of familial Parkinson’s disease. Hum Mol Genet pii: ddaa039. doi: 10.1093/hmg/ddaa039
  8. Buchholz VN, Mühle C, Cohort Study on Substance Use Risk Factors, Kornhuber J, Lenz B (2019) Lower Digit Ratio (2D:4D) Indicative of Excess Prenatal Androgen Is Associated With Increased Sociability and Greater Social Capital. Front Behav Neurosci 13: 246. doi: 10.3389/fnbeh.2019.00246
  9. Cantone M*, Küspert M*, Reiprich S*, Lai X, Eberhardt M, Gottle P, Beyer F, Azim K, Küry P, Wegner M, Vera J (2019) A gene regulatory architecture that controls region-independent dynamics of oligodendrocyte differentiation. Glia 67: 825-843. doi: 10.1002/glia.23569
  10. Cerrone F, Pozner T, Siddiqui A, Ceppi P, Winner B, Rajendiran M, Babu R, Ibrahim HS, Rodriguez BJ, Winkler J, Murphy KJ, O’Connor KE (2020) Polyhydroxyphenylvalerate/polycaprolactone nanofibers improve the life-span and mechanoresponse of human IPSC-derived cortical neuronal cells. Mater Sci Eng C Mater Biol Appl 111: 110832. doi: 10.1016/j.msec.2020.110832
  11. Elsesser O, Fröb F, Küspert M, Tamm ER, Fujii T, Fukunaga R, Wegner M (2019) Chromatin remodeler Ep400 ensures oligodendrocyte survival and is required for myelination in the vertebrate central nervous system. Nucleic Acids Research 47: 6208-6224. doi: 10.1093/nar/gkz376
  12. Endres D, Pruss H, Rauer S, Süß P, Venhoff N, Feige B, Schweizer T, Nickel K, Maier S, Egger K, Domschke K, Meyer PT, Tebartz van Elst L (2020) Probable Autoimmune Catatonia With Antibodies Against Cilia on Hippocampal Granule Cells and Highly Suspicious Cerebral FDG-Positron Emission Tomography Findings. Biol Psychiatry 87: e29-e31. doi: 10.1016/j.biopsych.2019.12.020
  13. Endres D, Rauer S, Kern W, Venhoff N, Maier SJ, Runge K, Süß P, Feige B, Nickel K, Heidt T, Domschke K, Egger K, Pruss H, Meyer PT, Tebartz van Elst L (2019) Psychiatric Presentation of Anti-NMDA Receptor Encephalitis. Front Neurol 10: 1086. doi: 10.3389/fneur.2019.01086
  14. Ettle B*, Kuhbandner K*, Jörg S, Hoffmann A, Winkler J, Linker RA (2016) alpha-Synuclein deficiency promotes neuroinflammation by increasing Th1 cell-mediated immune responses. J Neuroinflammation 13: 201. doi: 10.1186/s12974-016-0694-4
  15. Fiebig C, Keiner S, Ebert B, Schäffner I, Jagasia R, Lie DC, Beckervordersandforth R (2019) Mitochondrial Dysfunction in Astrocytes Impairs the Generation of Reactive Astrocytes and Enhances Neuronal Cell Death in the Cortex Upon Photothrombotic Lesion. Frontiers in Molecular Neuroscience 12:40. doi: 10.3389/fnmol.2019.00040
  16. Gegenhuber B, Weinland C, Kornhuber J, Mühle C*, Lenz B* (2018) OPRM1 A118G and serum beta-endorphin interact with sex and digit ratio (2D:4D) to influence risk and course of alcohol dependence. Eur Neuropsychopharmacol 28: 1418-1428. doi: 10.1016/j.euroneuro.2018.09.002
  17. Gonzalez-Alvarado MN, Rotger C, Berger L, London B, Haase S, Kuhbandner K, Lee DH, Linker RA (2020) Functional role of endogenous Kv1.4 in experimental demyelination. J Neuroimmunol 343: 577227. doi: 10.1016/j.jneuroim.2020.577227
  18. Hammer A, Waschbisch A, Kuhbandner K, Bayas A, Lee DH, Duscha A, Haghikia A, Gold R, Linker RA (2018) The NRF2 pathway as potential biomarker for dimethyl fumarate treatment in multiple sclerosis. Ann Clin Transl Neurol 5: 668-676. doi: 10.1002/acn3.553
  19. Hoffmann A, Ettle B, Battis K, Reiprich S, Schlachetzki JCM, Masliah E, Wegner M, Kuhlmann T, Riemenschneider MJ, Winkler J (2019) Oligodendroglial alpha-synucleinopathy-driven neuroinflammation in multiple system atrophy. Brain Pathol 29: 380-396. doi: 10.1111/bpa.12678
  20. Hoffmann A, Ettle B, Bruno A, Kulinich A, Hoffmann AC, von Wittgenstein J, Winkler J, Xiang W, Schlachetzki JCM (2016)Alpha-synuclein activates BV2 microglia dependent on its aggregation state. Biochem Biophys Res Commun 479: 881-886. doi: 10.1016/j.bbrc.2016.09.109
  21. Huber SE, Zoicas I, Reichel M, Mühle C, Büttner C, Ekici AB, Eulenburg V, Lenz B*, Kornhuber J*, Müller CP* (2018) Prenatal androgen receptor activation determines adult alcohol and water drinking in a sex-specific way. Addict Biol 23: 904-920. doi: 10.1111/adb.12540
  22. Jacob A*, Wüst HM*, Thalhammer JM, Fröb F, Küspert M, Reiprich S, Balta EA, Lie DC, Wegner M, Sock E (2018) The transcription factor prospero homeobox protein 1 is a direct target of SoxC proteins during developmental vertebrate neurogenesis. Journal of Neurochemistry 146: 251-268. doi: 10.1111/jnc.14456
  23. Jung M, Häberle BM, Tschaikowsky T, Wittmann MT, Balta EA, Stadler VC, Zweier C, Dörfler A, Gloeckner CJ, Lie DC (2018) Analysis of the expression pattern of the schizophrenia-risk and intellectual disability gene TCF4 in the developing and adult brain suggests a role in development and plasticity of cortical and hippocampal neurons. Molecular Autism 9:20. doi: 10.1186/s13229-018-0200-1
  24. Kaindl J*, Meiser I*, Majer J*, Sommer A, Krach F, Katsen-Globa A, Winkler J, Zimmermann H, Neubauer JC, Winner B (2019) Zooming in on Cryopreservation of hiPSCs and Neural Derivatives: A Dual-Center Study Using Adherent Vitrification. Stem Cells Translational Medicine 8: 247-259. doi: 10.1002/sctm.18-0121
  25. Kalinichenko LS, Hammad L, Reichel M, Kohl Z, Gulbins E, Kornhuber J, Müller CP (2019) Acid sphingomyelinase controls dopamine activity and responses to appetitive stimuli in mice. Brain Res Bull 146: 310-319. doi: 10.1016/j.brainresbull.2019.01.026
  26. Kalinichenko LS, Mühle C, Eulenburg V, Praetner M, Reichel M, Gulbins E, Kornhuber J, Müller CP (2019) Enhanced Alcohol Preference and Anxiolytic Alcohol Effects in Niemann-Pick Disease Model in Mice. Frontiers in Neurology 10:731. doi: 10.3389/fneur.2019.00731
  27. Kohl Z, Schlachetzki JC, Feldewerth J, Hornauer P, Munch M, Adame A, Riemenschneider MJ, Winkler J, Masliah E (2017) Distinct Pattern of Microgliosis in the Olfactory Bulb of Neurodegenerative Proteinopathies. Neural Plast 2017: 3851262. doi: 10.1155/2017/3851262
  28. Konrad EDH, Nardini N, Caliebe A, Nagel I, Young D, Horvath G, Santoro SL, Shuss C, Ziegler A, Bonneau D, Kempers M, Pfundt R, Legius E, Bouman A, Stuurman KE, Ounap K, Pajusalu S, Wojcik MH, Vasileiou G, Le Guyader G, Schnelle HM, Berland S, Zonneveld-Huijssoon E, Kersten S, Gupta A, Blackburn PR, Ellingson MS, Ferber MJ, Dhamija R, Klee EW, McEntagart M, Lichtenbelt KD, Kenney A, Vergano SA, Abou Jamra R, Platzer K, Ella Pierpont M, Khattar D, Hopkin RJ, Martin RJ, Jongmans MCJ, Chang VY, Martinez-Agosto JA, Kuismin O, Kurki MI, Pietilainen O, Palotie A, Maarup TJ, Johnson DS, Venborg Pedersen K, Laulund LW, Lynch SA, Blyth M, Prescott K, Canham N, Ibitoye R, Brilstra EH, Shinawi M, Fassi E, Study DDD, Sticht H, Gregor A, Van Esch H, Zweier C (2019) CTCF variants in 39 individuals with a variable neurodevelopmental disorder broaden the mutational and clinical spectrum. Genet Med 21: 2723-2733. doi: 10.1038/s41436-019-0585-z
  29. Kuhbandner K, Hammer A, Haase S, Terbrack E, Hoffmann A, Schippers A, Wagner N, Hussain RZ, Miller-Little WA, Koh AY, Stoolman JS, Segal BM, Linker RA, Stuve O (2019) MAdCAM-1-Mediated Intestinal Lymphocyte Homing Is Critical for the Development of Active Experimental Autoimmune Encephalomyelitis. Frontiers in Immunology 10:903. doi: 10.3389/fimmu.2019.00903
  30. Kuhbandner K, Hoffmann A, Gonzalez Alvarado MN, Seyler L, Bauerle T, Winkler J, Linker RA (2020) alpha-Synuclein: a Modulator During Inflammatory CNS Demyelination. J Mol Neurosci. doi: 10.1007/s12031-020-01498-8
  31. Lambrecht V, Hanspach J, Hoffmann A, Seyler L, Mennecke A, Straub S, Marxreiter F, Bäuerle T, Laun FB, Winkler J (2020) Quantitative susceptibility mapping depicts severe myelin deficit and iron deposition in a transgenic model of multiple system atrophy. Experimental Neurology. https://doi.org/10.1016/j.expneurol.2020.113314. Accepted 13 April 2020.
  32. Lazarevic V, Fienko S, Andres-Alonso M, Anni D, Ivanova D, Montenegro-Venegas C, Gundelfinger ED, Cousin MA, Fejtova A (2017) Physiological Concentrations of Amyloid Beta Regulate Recycling of Synaptic Vesicles via Alpha7 Acetylcholine Receptor and CDK5/Calcineurin Signaling. Front Mol Neurosci 10: 221. doi: 10.3389/fnmol.2017.00221
  33. Lenz B*, Bouna-Pyrrou P*, Mühle C, Kornhuber J (2018) Low digit ratio (2D:4D) and late pubertal onset indicate prenatal hyperandrogenziation in alcohol binge drinking. Prog Neuropsychopharmacol Biol Psychiatry 86: 370-378. doi: 10.1016/j.pnpbp.2018.02.012
  34. Lenz B, Eichler A, Schwenke E, Buchholz VN, Hartwig C, Moll GH, Reich K, Mühle C, Volz B, Titzmann A, Beckmann MW, Heinrich H, Kornhuber J, Fasching PA (2018) Mindfulness-based Stress Reduction in Pregnancy: an App-Based Programme to Improve the Health of Mothers and Children (MINDFUL/PMI Study). Geburtshilfe Frauenheilkd 78: 1283-1291. doi: 10.1055/a-0677-2630
  35. Lenz B, Köllner MG, Mühle C, Weinland C, Kornhuber J (2019) Basic Human Body Dimensions Relate to Alcohol Dependence and Predict Hospital Readmission. J Clin Med 8(12). pii: E2076. doi: 10.3390/jcm8122076
  36. Lenz B, Mühle C, Braun B, Weinland C, Bouna-Pyrrou P, Behrens J, Kubis S, Mikolaiczik K, Muschler MR, Saigali S, Sibach M, Tanovska P, Huber SE, Hoppe U, Eichler A, Heinrich H, Moll GH, Engel A, Goecke TW, Beckmann MW, Fasching PA, Muller CP, Kornhuber J (2017) Prenatal and adult androgen activities in alcohol dependence. Acta Psychiatr Scand 136: 96-107. doi: 10.1111/acps.12725
  37. Lenz B, Mühle C, Cohort Study on Substance Use Risk Factors, Kornhuber J (2019) Lower digit ratio (2D:4D) in alcohol dependence: Confirmation and exploratory analysis in a population-based study of young men. Addict Biol: e12815. doi: 10.1111/adb.12815
  38. Lenz B, Thiem D, Bouna-Pyrrou P, Mühle C, Stoessel C, Betz P, Kornhuber J (2016) Low digit ratio (2D:4D) in male suicide victims. J Neural Transm (Vienna) 123: 1499-1503. doi: 10.1007/s00702-016-1608-4
  39. Mehta P, Küspert M, Bale T, Brownstein CA, Towne MC, De Girolami U, Shi J, Beggs AH, Darras BT, Wegner M, Piao X, Agrawal PB (2017) Novel mutation in CNTNAP1 results in congenital hypomyelinating neuropathy. Muscle Nerve 55: 761-765. doi: 10.1002/mus.25416
  40. Mühle C, Barry B, Weinland C, Kornhuber J, Lenz B (2019) Estrogen receptor 1 gene variants and estradiol activities in alcohol dependence. Progress in Neuro-Psychopharmacology & Biological Psychiatry 92: 301-307. doi: 10.1016/j.pnpbp.2019.01.008
  41. Mühle C, Kornhuber J (2017) Assay to measure sphingomyelinase and ceramidase activities efficiently and safely. Journal of Chromatography A 1481: 137-144. doi: 10.1016/j.chroma.2016.12.033
  42. Mühle C, Kreczi J, Rhein C, Richter-Schmidinger T, Alexopoulos P, Doerfler A, Lenz B*, Kornhuber J* (2017) Additive sex-specific influence of common non-synonymous DISC1 variants on amygdala, basal ganglia, and white cortical surface area in healthy young adults. Brain Struct Funct 222: 881-894. doi: 10.1007/s00429-016-1253-6
  43. Mühle C, Wagner CJ, Farber K, Richter-Schmidinger T, Gulbins E, Lenz B, Kornhuber J (2019) Secretory Acid Sphingomyelinase in the Serum of Medicated Patients Predicts the Prospective Course of Depression. J Clin Med 8(6). pii: E846. doi: 10.3390/jcm8060846
  44. Mühle C, Weinland C, Gulbins E, Lenz B*, Kornhuber J* (2018) Peripheral Acid Sphingomyelinase Activity Is Associated with Biomarkers and Phenotypes of Alcohol Use and Dependence in Patients and Healthy Controls. Int J Mol Sci 19(12). pii: E4028. doi: 10.3390/ijms19124028
  45. Müller CP, Kalinichenko LS, Tiesel J, Witt M, Stockl T, Sprenger E, Fuchser J, Beckmann J, Praetner M, Huber SE, Amato D, Mühle C, Büttner C, Ekici AB, Smaga I, Pomierny-Chamiolo L, Pomierny B, Filip M, Eulenburg V, Gulbins E, Lourdusamy A, Reichel M, Kornhuber J (2017) Paradoxical antidepressant effects of alcohol are related to acid sphingomyelinase and its control of sphingolipid homeostasis. Acta Neuropathol 133: 463-483. doi: 10.1007/s00401-016-1658-6
  46. Muth KN, Piefke S, Weider M, Sock E, Hermans-Borgmeyer I, Wegner M, Küspert M (2016) The Dual-specificity phosphatase Dusp15 is regulated by Sox10 and Myrf in Myelinating Oligodendrocytes. Glia 64: 2120-2132. doi: 10.1002/glia.23044
  47. Newton T, Allison R, Edgar JR, Lumb JH, Rodger CE, Manna PT, Rizo T, Kohl Z, Nygren AOH, Arning L, Schule R, Depienne C, Goldberg L, Frahm C, Stevanin G, Durr A, Schols L, Winner B, Beetz C, Reid E (2018) Mechanistic basis of an epistatic interaction reducing age at onset in hereditary spastic paraplegia. Brain 141: 1286-1299. doi: 10.1093/brain/awy034
  48. Perez-Branguli F*, Buchsbaum IY*, Pozner T*, Regensburger M, Fan W, Schray A, Borstler T, Mishra H, Graf D, Kohl Z, Winkler J, Berninger B, Cappello S, Winner B (2019) Human SPG11 cerebral organoids reveal cortical neurogenesis impairment. Hum Mol Genet 28: 961-971. doi: 10.1093/hmg/ddy397
  49. Pons-Espinal M, de Luca E, Marzi MJ, Beckervordersandforth R, Armirotti A, Nicassio F, Fabel K, Kempermann G, De Pietri Tonelli D (2017) Synergic Functions of miRNAs Determine Neuronal Fate of Adult Neural Stem Cells. Stem Cell Reports 8: 1046-1061. doi: 10.1016/j.stemcr.2017.02.012
  50. Popp B, Krumbiegel M, Grosch J, Sommer A, Uebe S, Kohl Z, Plotz S, Farrell M, Trautmann U, Kraus C, Ekici AB, Asadollahi R, Regensburger M, Gunther K, Rauch A, Edenhofer F, Winkler J, Winner B, Reis A (2018) Need for high-resolution Genetic Analysis in iPSC: Results and Lessons from the ForIPS Consortium. Sci Rep 8: 17201. doi: 10.1038/s41598-018-35506-0
  51. Pozner T*, Schray A*, Regensburger M, Lie DC, Schlötzer-Schrehardt U, Winkler J, Turan S, Winner B (2018) Tideglusib Rescues Neurite Pathology of SPG11 iPSC Derived Cortical Neurons. Front Neurosci 12: 914. doi: 10.3389/fnins.2018.00914
  52. Prots I, Grosch J, Brazdis RM, Simmnacher K, Veber V, Havlicek S, Hannappel C, Krach F, Krumbiegel M, Schutz O, Reis A, Wrasidlo W, Galasko DR, Groemer TW, Masliah E, Schlötzer-Schrehardt U, Xiang W, Winkler J, Winner B (2018) alpha-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathies. Proc Natl Acad Sci U S A 115: 7813-7818. doi: 10.1073/pnas.1713129115
  53. Regensburger M, Minakaki G, Kettwig M, Eisenhut F, Haack T, Kohl Z, Winkler J (2020) Novel biallelic CTSD gene variants cause late-onset ataxia and retinitis pigmentosa. Mov Disord. 2020 May 18. doi: 10.1002/mds.28106. Online ahead of print
  54. Regensburger M, Prots I, Reimer D, Brachs S, Loskarn S, Lie DC, Mielenz D, Winner B (2018) Impact of Swiprosin-1/Efhd2 on Adult Hippocampal Neurogenesis. Stem Cell Reports 10: 347-355. doi: 10.1016/j.stemcr.2017.12.010
  55. Regensburger M, Schreglmann SR, Stoll S, Rockenstein E, Loskarn S, Xiang W, Masliah E, Winner B (2018) Oligomer-prone E57K-mutant alpha-synuclein exacerbates integration deficit of adult hippocampal newborn neurons in transgenic mice. Brain Structure & Function 223: 1357-1368. doi: 10.1007/s00429-017-1561-5
  56. Regensburger M, Tenner F, Mobius C, Schramm A (2018) Detection radius of EMG for fasciculations: Empiric study combining ultrasonography and electromyography. Clin Neurophysiol 129: 487-493. doi: 10.1016/j.clinph.2017.10.037
  57. Reichel M, Rhein C, Hofmann LM, Monti J, Japtok L, Langgartner D, Fuchsl AM, Kleuser B, Gulbins E, Hellerbrand C, Reber SO, Kornhuber J (2018) Chronic Psychosocial Stress in Mice Is Associated With Increased Acid Sphingomyelinase Activity in Liver and Serum and With Hepatic C16:0-Ceramide Accumulation. Front Psychiatry 9: 496. doi: 10.3389/fpsyt.2018.00496
  58. Reiprich S*, Cantone M*, Weider M*, Baroti T, Wittstatt J, Schmitt C, Küspert M, Vera J, Wegner M (2017) Transcription factor Sox10 regulates oligodendroglial Sox9 levels via microRNAs. Glia 65: 1089-1102. doi: 10.1002/glia.23146
  59. Reyes JF, Sackmann C, Hoffmann A, Svenningsson P, Winkler J, Ingelsson M, Hallbeck M (2019) Binding of alpha-synuclein oligomers to Cx32 facilitates protein uptake and transfer in neurons and oligodendrocytes. Acta Neuropathol 138: 23-47. doi: 10.1007/s00401-019-02007-x
  60. Rhein C, Reichel M, Kramer M, Rotter A, Lenz B, Mühle C, Gulbins E, Kornhuber J (2017) Alternative splicing of SMPD1 coding for acid sphingomyelinase in major depression. J Affect Disord 209: 10-15. doi: 10.1016/j.jad.2016.09.019
  61. Schäffner I, Minakaki G, Khan MA, Balta EA, Schlötzer-Schrehardt U, Schwarz TJ, Beckervordersandforth R, Winner B, Webb AE, DePinho RA, Paik J, Wurst W, Klucken J, Lie DC (2018) FoxO Function Is Essential for Maintenance of Autophagic Flux and Neuronal Morphogenesis in Adult Neurogenesis. Neuron 99(6):1188-1203.e6. doi: 10.1016/j.neuron.2018.08.017
  62. Straub J, Gregor A, Sauerer T, Fliedner A, Distel L, Suchy C, Ekici AB, Ferrazzi F, Zweier C (2020) Genetic interaction screen for severe neurodevelopmental disorders reveals a functional link between Ube3a and Mef2 in Drosophila melanogaster. Sci Rep 10: 1204. doi: 10.1038/s41598-020-58182-5
  63. Straub J*, Konrad EDH*, Grüner J, Toutain A, Bok LA, Cho MT, Crawford HP, Dubbs H, Douglas G, Jobling R, Johnson D, Krock B, Mikati MA, Nesbitt A, Nicolai J, Phillips M, Poduri A, Ortiz-Gonzalez XR, Powis Z, Santani A, Smith L, Stegmann APA, Stumpel C, Vreeburg M, Study DDD, Fliedner A, Gregor A, Sticht H, Zweier C (2018) Missense Variants in RHOBTB2 Cause a Developmental and Epileptic Encephalopathy in Humans, and Altered Levels Cause Neurological Defects in Drosophila. American Journal of Human Genetics 102: 44-57. doi: 10.1016/j.ajhg.2017.11.008
  64. Süß P*, Hoffmann A*, Rothe T*, Ouyang Z, Baum W, Staszewski O, Schett G, Prinz M, Kronke G, Glass CK, Winkler J, Schlachetzki JCM (2020) Chronic Peripheral Inflammation Causes a Region-Specific Myeloid Response in the Central Nervous System. Cell Rep 30: 4082-4095 e6. doi: 10.1016/j.celrep.2020.02.109
  65. Turan S, Börstler T, Kavyanifar A, Loskarn S, Reis A, Winner B, Lie DC (2019) A novel human stem cell model for Coffin-Siris Syndrome like syndrome reveals the importance of SOX11 dosage for neuronal differentiation and survival. Hum Mol Genet pii: ddz089. doi: 10.1093/hmg/ddz089
  66. Turnescu T, Arter J, Reiprich S, Tamm ER, Waisman A, Wegner M (2018) Sox8 and Sox10 jointly maintain myelin gene expression in oligodendrocytes. Glia 66: 279-294. doi: 10.1002/glia.23242
  67. Vogel JK, Weider M, Engler LA, Hillgartner S, Schmitt C, Hermans-Borgmeyer I, Wegner M (2019) Sox9 overexpression exerts multiple stage-dependent effects on mouse spinal cord development. Glia 68(5):932-946. doi: 10.1002/glia.23752
  68. von Wittgenstein J, Zheng F, Wittmann MT, Balta EA, Ferrazzi F, Schäffner I, Häberle BM, Valero-Aracama MJ, Koehl M, Miranda CJ, Kaspar BK, Ekici AB, Reis A, Abrous DN, Alzheimer C, Lie DC (2020) Sox11 is an Activity-Regulated Gene with Dentate-Gyrus-Specific Expression Upon General Neural Activation. Cereb Cortex pii: bhz338. doi: 10.1093/cercor/bhz338
  69. Wagner CJ, Musenbichler C, Böhm L, Färber K, Fischer AI, von Nippold F, Winkelmann M, Richter-Schmidinger T, Mühle C, Kornhuber J, Lenz B (2019) LDL cholesterol relates to depression, its severity, and the prospective course. Prog Neuropsychopharmacol Biol Psychiatry 92: 405-411. doi: 10.1016/j.pnpbp.2019.01.010
  70. Wedel M, Fröb F, Elsesser O, Wittmann MT, Lie DC, Reis A, Wegner M (2020) Transcription factor Tcf4 is the preferred heterodimerization partner for Olig2 in oligodendrocytes and required for differentiation. Nucleic Acids Res pii: gkaa218. doi: 10.1093/nar/gkaa218
  71. Wegener A, Küspert M, Sock E, Philipsen S, Suske G, Wegner M (2017) Sp2 is the only glutamine-rich specificity protein with minor impact on development and differentiation in myelinating glia. J Neurochem 140: 245-256. doi: 10.1111/jnc.13908
  72. Weider M*, Starost LJ*, Groll K*, Küspert M, Sock E, Wedel M, Fröb F, Schmitt C, Baroti T, Hartwig AC, Hillgärtner S, Piefke S, Fadler T, Ehrlich M, Ehlert C, Stehling M, Albrecht S, Jabali A, Schöler HR, Winkler J, Kuhlmann T, Wegner M (2018)Nfat/calcineurin signaling promotes oligodendrocyte differentiation and myelination by transcription factor network tuning. Nature Communications 9(1):899. doi: 10.1038/s41467-018-03871-z
  73. Weinland C, Braun B, Mühle C, Kornhuber J, Lenz B (2017) Cloninger Type 2 Score and Lesch Typology Predict Hospital Readmission of Female and Male Alcohol-Dependent Inpatients During a 24-Month Follow-Up. Alcohol Clin Exp Res 41: 1760-1767. doi: 10.1111/acer.13468
  74. Weinland C, Mühle C, Kornhuber J, Lenz B (2019) Body mass index and craving predict 24-month hospital readmissions of alcohol-dependent in-patients following withdrawal. Prog Neuropsychopharmacol Biol Psychiatry 90: 300-307. doi: 10.1016/j.pnpbp.2018.11.019
  75. Weinland C, Mühle C, Kornhuber J, Lenz B (2019) Crossed Eye/Hand Laterality and Left-Eyedness Predict a Positive 24-Month Outcome in Alcohol-Dependent Patients. Alcohol Clin Exp Res 43: 1308-1317. doi: 10.1111/acer.14051
  76. Weinland C, Tanovska P, Kornhuber J, Mühle C*, Lenz B* (2020) Serum lipids, leptin, and soluble leptin receptor in alcohol dependence: A cross-sectional and longitudinal study. Drug Alcohol Depend 209: 107898. doi: 10.1016/j.drugalcdep.2020.107898
  77. Wihan J, Grosch J, Kalinichenko LS, Müller CP, Winkler J, Kohl Z (2019) Layer-specific axonal degeneration of serotonergic fibers in the prefrontal cortex of aged A53T alpha-synuclein-expressing mice. Neurobiol Aging 80: 29-37. doi: 10.1016/j.neurobiolaging.2019.03.014
  78. Wittstatt J, Weider M, Wegner M, Reiprich S (2020) MicroRNA miR-204 regulates proliferation and differentiation of oligodendroglia in culture. Glia. doi: 10.1002/glia.23821
  79. Yambire KF, Fernandez-Mosquera L, Steinfeld R, Mühle C, Ikonen E, Milosevic I, Raimundo N (2019) Mitochondrial biogenesis is transcriptionally repressed in lysosomal lipid storage diseases. Elife 8. pii: e39598. doi: 10.7554/eLife.39598
  80. Zeitler S*, Ye L*, Andreyeva A, Schumacher F, Monti J, Nurnberg B, Nowak G, Kleuser B, Reichel M, Fejtova A, Kornhuber J, Rhein C, Friedland K (2019) Acid sphingomyelinase – a regulator of canonical transient receptor potential channel 6 (TRPC6) activity. Journal of Neurochemistry 150: 678-690. doi: 10.1111/jnc.14823

* contributed equally

 

Reviews/ Comments/ Letters/ Book Chapter (peer-reviewed):

  1. Ardura-Fabregat A, Boddeke E, Boza-Serrano A, Brioschi S, Castro-Gomez S, Ceyzeriat K, Dansokho C, Dierkes T, Gelders G, Heneka MT, Hoeijmakers L, Hoffmann A, Iaccarino L, Jahnert S, Kuhbandner K, Landreth G, Lonnemann N, Loschmann PA, McManus RM, Paulus A, Reemst K, Sanchez-Caro JM, Tiberi A, Van der Perren A, Vautheny A, Venegas C, Webers A, Weydt P, Wijasa TS, Xiang X, Yang Y (2017) Targeting Neuroinflammation to Treat Alzheimer’s Disease. CNS Drugs 31: 1057-1082. doi: 10.1007/s40263-017-0483-3
  2. Beckervordersandforth R (2017) Mitochondrial Metabolism-Mediated Regulation of Adult Neurogenesis. Brain Plast 3: 73-87. doi: 10.3233/BPL-170044
  3. Beckervordersandforth R (2017) Newborn Neurons in the Aged Hippocampus-Scarce and Slow but Highly Plastic. Cell Rep 21: 1127-1128. doi: 10.1016/j.celrep.2017.10.049
  4. Beckervordersandforth R, Rolando C (2019) Untangling human neurogenesis to understand and counteract brain disorders. Curr Opin Pharmacol 50: 67-73. doi: 10.1016/j.coph.2019.12.002
  5. Enders M, Heider T, Ludwig A, Kuerten S (2020) Strategies for Neuroprotection in Multiple Sclerosis and the Role of Calcium. Int J Mol Sci 21(5). pii: E1663. doi: 10.3390/ijms21051663
  6. Fliedner A, Zweier C (2018) X-chromosomale Entwicklungsstörungen im weiblichen Geschlecht. medizinische genetik, vol 30. Springer Medizin, pp 334–341
  7. Kaindl J, Winner B (2019) Disease Modeling of Neuropsychiatric Brain Disorders Using Human Stem Cell-Based Neural Models. Curr Top Behav Neurosci 42: 159-183. doi: 10.1007/7854_2019_111
  8. Kavyanifar A*, Turan S*, Lie DC (2018) SoxC transcription factors: multifunctional regulators of neurodevelopment. Cell Tissue Res 371: 91-103. doi: 10.1007/s00441-017-2708-7
  9. Kuhbandner K (2018) Uncovering the Role of Sox2 in Oligodendroglia. J Neurosci 38: 4460-4461. doi: 10.1523/JNEUROSCI.0556-18.2018
  10. Lenz B, Röther M, Bouna-Pyrrou P, Mühle C, Tektas OY, Kornhuber J (2019) The androgen model of suicide completion. Prog Neurobiol 172: 84-103. doi: 10.1016/j.pneurobio.2018.06.003
  11. Marxreiter F, Stemick J, Kohl Z (2020) Huntingtin Lowering Strategies. Int J Mol Sci 21(6). pii: E2146. doi: 10.3390/ijms21062146
  12. Mészáros L, Hoffmann A, Wihan J, Winkler J (2020) Current Symptomatic and Disease-Modifying Treatments in Multiple System Atrophy. Int. J. Mol. Sci., 2020 Apr 16;21(8):2775. doi: 10.3390/ijms21082775.
  13. Mühle C, Bilbao Canalejas RD, Kornhuber J (2019) Sphingomyelin Synthases in Neuropsychiatric Health and Disease. Neurosignals 27: 54-76. doi: 10.33594/000000200
  14. Pozner T*, Regensburger M*, Engelhorn T, Winkler J, Winner B (2020) Janus-faced spatacsin (SPG11): involvement in neurodevelopment and multisystem neurodegeneration. Brain. 2020 May 1;awaa099. doi: 10.1093/brain/awaa099. Online ahead of print.
  15. Salar S, Guhathakurta D*, Marx Hofmann L* (2019) Differential contribution of pyramidal cells and interneurons to activity-dependent gene transcription changes. J Neurophysiol 122: 2203-2205. doi: 10.1152/jn.00089.2019
  16. Schneider J, Karpf J, Beckervordersandforth R (2019) Role of Astrocytes in the Neurogenic Niches. Methods Mol Biol 1938: 19-33. doi: 10.1007/978-1-4939-9068-9_2
  17. Simmnacher K*, Lanfer J*, Rizo T*, Kaindl J*, Winner B (2019) Modeling Cell-Cell Interactions in Parkinson’s Disease Using Human Stem Cell-Based Models. Front Cell Neurosci 13: 571. doi: 10.3389/fncel.2019.00571
  18. Süß P, Schlachetzki JCM (2020) Microglia in Alzheimer’s Disease. Curr Alzheimer Res 17(1):29-43. doi: 10.2174/1567205017666200212155234
  19. Wittmann MT, Häberle BM (2018) Linking the Neuropsychiatric Disease Gene TCF4 to Neuronal Activity-Dependent Regulatory Networks. Journal of Neuroscience 38: 2653-2655. doi: 10.1523/Jneurosci.3475-17.2018
  20. Wittstatt J, Reiprich S, Küspert M (2019) Crazy Little Thing Called Sox-New Insights in Oligodendroglial Sox Protein Function. Int J Mol Sci 20(11). pii: E2713. doi: 10.3390/ijms20112713
  21. Wüst HM, Wegner M (2018) Oncogenic insult to the brain: sox proteins rise to the occasion. Translational Cancer Research: S31-S33. doi: 10.21037/tcr.2017.12.19

* contributed equally

 

Other Publications

  1. Regensburger M (2020) Which kinds of fasciculations are missed by ultrasonography in ALS? Clin Neurophysiol 131: 237-238. doi: 10.1016/j.clinph.2019.09.011
  2. Regensburger M, Mielenz D, Winner B (2018) Swiprosin-1/EFhd2 – another piece in the puzzle of tauopathy? Aging (Albany NY) 10: 522-523. doi: 10.18632/aging.101431
  3. Regensburger M, Weidner N, Kohl Z (2018) Motor neuron diseases. Clinical and genetic differential diagnostics. Nervenarzt 89: 658-665. doi: 10.1007/s00115-018-0524-2