The RTG joins scientists with expertise in basic, clinical and translational neuroscience to tackle Neurodevelopment and Vulnerability of the CNS from multiple angles to find novel interdisciplinary approaches.
Institute of Physiology and Pathophysiology
Chair of Physiology
- Phone number: +49 9131 85-22295
- Email: firstname.lastname@example.org
- Website: http://www.physiologie1.uni-erlangen.de/en/Alzheimer/index.shtml
1985 MD, LMU München
1987 Postdoctoral Fellow, LMU München
1991 Postdoctoral Fellow, University of Washington, Seattle, USA
1993 Group leader, LMU München
1996 Heisenberg Fellow, LMU München
2002 Professor of Phsyiology and Director, Institute of Physiology, Christian-Albrechts-Universität Kiel
2008 Professor of Physiology and Chairman, Institute of Physiology and Pathophysiology, Friedrich-Alexander-Universität Erlangen-Nürnberg
Our research focuses on the electric behavior of CNS neurons under normal and pathological conditions. Using high-resolution neurophysiologic and optical techniques, we investigate function and regulation of ion channels and synapses.
Our aim is to understand fundamental neural processes which are essential for cognitive and motor functions as well as for affective behavior and whose dysfunctions might give rise to neuropsychiatric disorders.
Role of activin in development-related neuropsychiatric disorders
Institute of Biochemistry
- Phone number: +49 9131 85-24146
- Email: email@example.com
- Website: https://www.biochemie.med.fau.de/forschung/ag-beckervordersandforth-de/
2003 Diploma in Biology, University of Münster
2007 PhD, Institute of Genetics, Johannes-Gutenberg University of Mainz
2008 Postdoctoral Fellow, Institute of Stem Cell Research, Helmholtz Centre Munich
2012 Postdoctoral Fellow, Institute of Developmental Genetics, Helmholtz Centre Munich
2013 Senior Research Fellow, Institute of Biochemistry, FAU Erlangen-Nürnberg
2017 Independant Group Leader, Institute of Biochemistry, FAU Erlangen-Nürnberg
Interaction of stem cells and their progeny with their microenvironment is critical for regulation of hippocampal neurogenesis. Astrocytes are considered major components of the hippocampal neurogenic niche, but their specific contribution to neurogenesis-dependent plasticity remains largely understudied. In contrast to the prevailing assumption that mature astrocytes are postmitotic in the non-injured adult brain, I recently identified astrocyte subtypes, which started to proliferate in response to pro- or anti-neurogenic stimuli, thus revealing unexpected astrocyte plasticity. In my research I pursue the novel hypothesis that astrocyte heterogeneity and astrogenesis are critical modulators of neurogenesis-dependent plasticity.
Contribution of astrocytes to synapse formation in adult-born hippocampal neurons
Johann Helmut Brandstätter
1988 PhD, Karl Franzens University, Graz, Austria
1988 Postdoctoral Fellow, Life Sciences Centre, Dalhousie University, Halifax, Canada
1992 Research Assistant, Department of Biology, University of Freiburg
1992 Max Planck Fellow, Max Planck Institute for Brain Research, Frankfurt/Main
1993 Research Group Leader, Max Planck Institute for Brain Research, Frankfurt/Main
1998 Heisenberg Fellow, Max Planck Institute for Brain Research, Frankfurt/Main
2004 Professor of Animal Physiology/ Neurobiology, Magdeburg, FAU Erlangen-Nürnberg
2006 Professor and Chair of Animal Physiology/ Neurobiology, FAU Erlangen-Nürnberg
The research of the Brandstätter and Regus-Leidig group focuses on molecules and mechanisms that play a role in the development and the structural and functional organization of chemical synapses in the CNS with a special focus on the retina. In our experimental approach, we combine methods ranging from immunocytochemistry and light- and electron microscopical imaging to biochemistry, cell and molecular biology, and electrophysiology.
As synaptophathies = malfunctioning synapses are a reason for many neurodegenerative diseases and neurological disorders, the aim of our research is to contribute to a better understanding of synapse function in health and disease.
Examining the synaptogenesis and synapse maintenance factor Bassoon as a vulnerability factor in photoreceptors to late-onset degeneration
2003 Dr. sc. nat. and PhD in Neuroscience, University of Zurich, Switzerland
2003 Fellow of Swiss National Foundation, Leibniz Institute of Neurobiology, Magdeburg
2005 Postdoctoral Fellow, Leibniz Institute of Neurobiology, Magdeburg
2009 Group Leader, Leibniz Institute of Neurobiology, Magdeburg
2013 Independant Junior Research Group Leader, Leibniz Institute of Neurobiology, Magdeburg
2016 Professor, FAU Erlangen-Nürnberg
My group is interested in the cellular and molecular mechanisms underlying plasticity of presynaptic function in healthy brain and in disease.
The project aims to further increase the understanding of the pathophyiological link between development and the pathogenesis of adult-onset neuropsychiatric and -degenerative disease by systematically investigating critical regulators of activity-dependent gene expression.
2001 VetMD, University of Leipzig
2007 PhD in Physics, University of Leipzig
2007 Postdoctoral Fellow, University of Cambridge
2011 University Lecturer, University of Cambridge
2017 University Reader in Neuronal Mechanics, University of Cambridge
2020 Full Professor of Neuronal Mechanics, University of Cambridge
2020 Alexander von Humboldt-Professor and Chair of the Institute for Medical Physics and Microtissue Engineering, Friedrich-Alexander Universität Erlangen-Nürnberg
2020 Scientific Board, Max-Planck-Zentrum für Physik und Medizin, Erlangen
We are working at the interface between physical and life sciences to understand how mechanical signals, such as cellular forces and local tissue stiffness, regulate developmental and regenerative processes in the nervous system.
We will investigate whether and how demyelination-induced alterations of tissue mechanics affect axonal regeneration and how the neuron senses alterations in tissue mechanics during ageing and in demyelinating diseases. The knowledge gained from this project will lead to a better understanding of how developmental programmes could be exploited to promote regeneration.
2003 Graduation Diplom Biologie, LMU Munich
2004-2008 PhD, LMU Munich
2009-2011 Postdoctoral Fellow Stanford University, Palo Alto, CA, USA
2011-2014 Postdoctoral Scientist in the lab of Prof. Benedikt Berninger, LMU Munich
2014-2019 Group Leader Physiological Genomics, BMC Munich
2019 – now W2 Professor Institute of Biochemistry, FAU Erlangen-Nürnberg
In the lab we are studying processes that govern human neuron formation by using a dual approach which entails forced and natural neurogenesis using direct lineage reprogramming and the brain organoid model, respectively.
We are using primary cultures of human brain pericytes to dissect the molecular mechanisms underlying fate conversion of pericytes into induced neurons. Furthermore, we use (patient-derived) human iPS cells to generate three-dimensional cell aggregates termed brain organoids to study aspects of early human neurogenesis. Besides using single cell transcriptomics, we are also using continuous live imaging to follow the trajectories on a single cell level.
Revealing the origin of corpus callosum aberrations by employing a human brain organoid-based model system
1985 MD, University of Ulm
1986 Postdoctoral Fellow, Department of Psychiatry, University of Würzburg
1989 Associate Professor of Psychiatry, University of Würzburg
1996 Associate Professor, Head of Gerontopsychiatric Unit, University of Göttingen
2000 Professor and Chair, Department of Psychiatry, Friedrich-Alexander-Universität Erlangen-Nürnberg
Our research focuses on sphingolipid metabolism and neuropsychiatric disorders, on the pathophysiology of major depressive disorder and Alzheimer’s disease and on the early and differential diagnosis of Alzheimer’s disease.
Basic and translational investigations into the role of the sphingolipid enzyme sphingomyelin synthase in the pathophysiology and treatment of major depression
2008 Diploma degree in Biology, FAU Erlangen-Nürnberg
2008 Graduate student, FAU Erlangen-Nürnberg
2012 Postdoctoral fellow, Institute of Biochemistry, FAU Erlangen-Nürnberg
2019 Group leader, Institute of Biochemistry, FAU Erlangen-Nürnberg
My research focuses on the identification and functional analysis of novel regulators and modifiers of glial development and myelination in vitro and in vivo. To obtain a better understanding of transcriptional regulatory networks, which jointly work together during glial development to enable proper myelination and remyelination, I focus on potential targets and interactors of known key regulators of myelination processes, such as the transcription factors Sox10 and Myrf in oligodendrocytes.
The role of Dusp15/VHY during oligodendrocyte differentiation and myelination
Dieter Chichung Lie
Institute of Biochemistry
Professorship of Molecular Medicine with focus on Molecular Imaging
- Phone number: +49 9131 85-24622
- Email: firstname.lastname@example.org
- Website: http://www.biochem.fau.de/forschung/arbeitsgruppe.php?arbeitsgruppe=5
1998 MD, RWTH Aachen
1999 Postdoctoral Fellow, The Salk Institute for Biological Studies
2005 Group Leader, Helmholtz Center Munich
2011 Professor for Molecular Medicine and Molecular Imaging, Medical Faculty, Friedrich-Alexander Universität Erlangen-Nürnberg
Adult hippocampal neurogenesis – the generation of hippocampal neurons from stem cells throughout life – is a prime example of how the continuous activity of neurodevelopmental processes shapes plasticity of the adult brain. Notably, impaired adult neurogenesis is evolving as a major contributor to neuropsychiatric symptoms in ageing, mental and neurodegenerative diseases.
Research in my group aims to understand the molecular and cell biological mechanisms controlling adult hippocampal neurogenesis with a major focus on transcriptional and metabolic regulation.
Role of the neurodevelopmental transcription factor Sox11 in shaping adult CNS function in physiology and disease
Department of Psychiatry and Psychotherapy
Chair of Psychiatry and Psychotherapy
2001 Diploma in Biochemistry, Leipzig University
2001 PhD student at the Friedrich-Alexander University of Erlangen-Nuernberg (FAU)
2007 Research Assistant at the Medical University of Innsbruck (MUI)
2008 Postdoctoral Fellow at the Department of Psychiatry and Psychotherapy, University Hospital Erlangen/ FAU
2013 Head of departmental biobanking at the Molecular Neurobiology Laboratories
2019 Group Leader “Biomarkers in Psychiatry”, Department of Psychiatry and Psychotherapy, University Hospital Erlangen/ FAU
Recent data strongly indicate the influence of the sphingolipid metabolism in the pathophysiology of neuropsychiatric diseases such as depression, alcohol addiction and neurodegeneration. We characterize the involved sphingomyelinase and ceramidase enzymes in various biological materials and investigate their genetic variation, activity and regulation in animal / cell culture models, healthy individuals and patients. Thereby we aim to better understand the underlying molecular mechanisms as well as to evaluate the suitability of these enzymes as diagnostic or prognostic biomarkers and as preventive and therapeutic targets.
Basic and translational investigations into the role of the sphingolipid enzyme sphingomyelin synthase in the pathophysiology and treatment of major depression
Institute of Human Genetics
Chair of Human Genetics
- Phone number: +49 9131 85-22020
- Email: email@example.com
- Website: http://www.humangenetik.uk-erlangen.de/forschung/arbeitsgruppen/index_ger.html
1986 MD, Universities of Göttingen und Lübeck
1986 Postdoctoral fellow, Inst. of Human Genetics, Univ. of Göttingen
1990 Group leader, Inst. of Human Genetics, Humboldt Univ. Berlin
1995 Founder and Project Leader, “Gene Mapping Centre” at Max-Delbrück-Center (MDC), Berlin
1998 Associate Professor, Humboldt Univ. Berlin
2000 Professor of Human Genetics at the FAU Erlangen-Nürnberg and Director of the Institute of Human Genetics at the University Hospital Erlangen
Genetic basis of neurocognitive disorders – the majority of these disorders, especially those with moderate to severe intellectual impairment, are caused by major genetic defects, but the genetic heterogeneity is extremely high, making their elucidation a challenge. In recent years, though, common pathways and cellular processes have emerged making identification of causative genes and the study of their pathophysiology an excellent avenue to understand cognition and eventually find treatments for affected individuals.
Research in my group aims to understand the genetic defects and molecular mechanisms controlling all process leading to disturbed cognition with a major focus on chromatin related processes of transcriptional control.
Identification of transcriptional networks underlying corpus callosum dysgenesis in neurodevelopmental and neuropsychiatric disease
1999 – 2006 Medical Studies at Julius-Maximilians University Wuerzburg, Germany, University of Toronto, Canada, Université de Strasbourg, France
2006 – 2007 Resident in Neurology, Heinrich Heine University Duesseldorf
2007 – 2013 Resident in Neurology, Klinikum rechts der Isar, TU Munich
2013 Board Certification in Neurology
2014 – 2018 Research Fellow (DFG) in Neuroimmunology, Harvard Medical School, Boston, MA, USA
2018 – 2020 Attennding Physician and Heisenberg Fellow, Department of Neurology, Klinikum rechts der Isar, TU Munich
From 9/2020 Full Professor (W3), Heisenberg Professor for Neuroimmunology, and ERC Starting Grantee, Department of Neurology, FAU Erlangen-Nürnberg
Astrocytes and microglia are the most abundant glial cells in the CNS with important functions in development, health and disease. Indeed, their interactions determine developmental processes as well as the outcome in autoimmune inflammatory, degenerative and ischemic disorders of the CNS. In this context, we have shown that the interaction of glial cells with metabolites derived from the gut flora alters the outcome in inflammatory CNS disorders by the interaction of dietary metabolites with the Aryl hydrocarbon receptor (AHR) in astrocytes and microglia. Combining clinical studies with preclinical disease models, we aim to unravel mechanisms controlled by glial cells and their interaction with gut-derived AHR ligands during development, health and disease. Our ultimate goal is to gain a deeper understanding of the underlying mechanisms and to develop novel therapeutic interventions for developmental disorders as well as CNS diseases such as Multiple Sclerosis, Neuromyelitis optica and ischemic stroke.
Role of aryl hydrocarbon receptor on function and immune response of astrocytes
1990 Dr. rer. nat., Julius-Maximilians-Universität Würzburg
1990 Postdoctoral Fellow, CMM, University of California at San Diego (UCSD)
1994 Group Leader, Centre for Molecular Neurobiology Hamburg (ZMNH)
2000 Chair of Biochemistry and Pathobiochemistry, Institute of Biochemistry, Friedrich-Alexander Universität Erlangen-Nürnberg
Myelination is a central function of glial cells in the vertebrate nervous system, and essential during development as well as in the adult as evident from the fact that myelination defects cause a variety of diseases that manifest at different times of life including leukodystrophies, autism spectrum disorders, schizophrenia, and multiple sclerosis.
Research in my group aims to understand the molecular mechanisms controlling gliogenesis, glial identity and homeostasis as well as myelination in the vertebrate central and peripheral nervous systems with a major focus on transcriptional regulation.
The developmental regulator Sox8 as a determinant of glial disease in the adult CNS
1986 M.D., School of Medicine, Albert-Ludwigs University, Freiburg and Louis-Pasteur University, Strasbourg (France)
1986 Residency in Neurology, Julius-Maximilians University Würzburg
1992 Postdoctoral fellow, Department of Neurosciences, University of California San Diego (UCSD) and McDonnell-Pew Center, Salk Institute, La Jolla
1995 Assistant Adjunct Professor of Neurosciences, UCSD
2002 Professor of Clinical Neurobiology, University of Regensburg
2008 Head of the Divison of Molecular Neurology and Movement Disorder Center, University Hospital Erlangen
2017 Member Governing Board, University Hospital Erlangen, and Vice Dean, Medical Faculty, FAU Erlangen-Nürnberg
The underlying molecular and cellular mechanisms in neurodegenerative diseases such as synucleinopathies are examined by using innovative translational neuroscience approaches in order to define the impact on the endogenous regenerative potential within the diseased brain, in particular the generation of new neurons and oligodendroglia. Furthermore, by taking advantage of our outpatient clinic we established human induced pluripotent stem cells and neural progeny for disease modelling purposes. The overall hypothesis is that impaired adult neuro- and oligodendrogenesis may contribute to distinct disease phenotypes. The present project investigates the functional consequences of alpha-synuclein pathology in oligodendrocytes with particular focus on myelin homeostasis.
Oligodendrogenesis and myelin homeostasis in alpha-synucleinopathies
1999 MD, Universities of Regensburg and Würzburg
2005 Specialist, Neurology, Universität Regensburg, Klinik und Poliklinik für Neurologie
2007 Humboldt Fellow, Research Associate, The Salk Institute for Biological Studies
2010 IZKF Junior Group Leader/ BMBF Research Group Leader Neuroscience, FAU Erlangen-Nürnberg
The overall goal of research in our laboratory is to model neurodegenerative diseases using stem cells. Specifically, we investigate neurodegeneration and regeneration in synucleinopathies including Parkinson’s disease and motor neuron diseases.
Function of the hereditary spastic paraplegia disease gene SPG11 in development and degeneration of the corpus callosum
Department of Neurology
Divison of Molecular Neurology
- Phone number: +49 9131 85-34492
- Email: firstname.lastname@example.org
- Website: https://www.uk-erlangen.de/kontakt/visitenkarte/friederike-zunke-10827/
2010 Bachelor of Science (B.Sc.) in Biochemistry, University of Kiel, Germany
2011 Master of Research (M.Res.) in Biomedical Sciences, St. Georges University of London, United Kingdom
2015 Dissertation (Dr. rer. nat.) in Biochemistry, Department of Biochemistry, University of Kiel, Germany
2015-2016 Postdoctoral fellow, Department of Neurology, Northwestern University, Chicago, USA
2016-2020 Postdoctoral fellow, independent group Leader, Institute of Biochemistry, University of Kiel, Germany
2020 W1 Professor for Translational Neurosciences, Department of Molecular Neurology, University Hospital Erlangen / FAU Erlangen Nürnberg
2021 IZKF Junior Group Leader, FAU Erlangen-Nürnberg
In our laboratory, we are interested in the cellular and molecular disease mechanisms involved in Synucleinopathies, which are characterized by -Synuclein aggregation and include Parkinson’s disease and Multiple System Atrophy (MSA). Thereby our main focus is on protein aggregation and degradation pathways that involve lysosomal function and homeostasis. We are specialized in tools and readouts to analyze lysosomal function and homeostasis in various cell models. Our main techniques involve protein-biochemical and -structural analyses as well as induced pluripotent stem cell (iPSC) systems and neuronal differentiation protocols.
Consequences of -Synuclein-mediated Lysosomal Dysfunction on Oligodendrogenesis and myelination