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Graduates

Graduates

Congratulations to all our graduates who successfully defended their thesis and completed the programme!

 

Daniela Anni

Graduate student

Department of Psychiatry and Psychotherapy
Prof. Anna Fejtová

Supervisor

Project Title: Physiological regulation of the synaptic plasticity by Aβ and related APP derived fragments

Publications:

Montenegro-Venegas C*, Fienko S*, Anni D*, Pina-Fernández E, Frischknecht R, Fejtova A (2020) Bassoon inhibits proteasome activity via interaction with PSMB4. Cell Mol Life Sci. 2020 Jul 10. doi: 10.1007/s00018-020-03590-z. *contributed equally

Lazarevic V, Fieńko S, Andres-Alonso M, Anni D, Ivanova D, Montenegro-Venegas C, Gundelfinger ED, Cousin MA, Fejtova A (2017) Physiological Concentrations of Amyloid Beta Regulate Recycling of Synaptic Vesicles via Alpha7 Acetylcholine Receptor and CDK5/Calcineurin Signaling. Front Mol Neurosci. 21;10:221.

Alana Hoffmann

Graduate student

Department for Molecular Neurology
Prof. Jürgen Winkler

Supervisor

Project Title: Immune response and alpha-synuclein: interplay in neurodegeneration and –inflammation

Publications:

Süß P*, Hoffmann A*, Rothe T*, Ouyang Z, Baum W, Staszewski O, Schett G, Prinz M, Kronke G, Glass CK, Winkler J, Schlachetzki JCM (2020) Chronic Peripheral Inflammation Causes a Region-Specific Myeloid Response in the Central Nervous System. Cell Rep 30: 4082-4095 e6. doi: 10.1016/j.celrep.2020.02.109 *equal contribution

Lambrecht V, Hanspach J, Hoffmann A, Seyler L, Mennecke A, Straub S, Marxreiter F, Bäuerle T, Laun FB, Winkler J (2020) Quantitative susceptibility mapping depicts severe myelin deficit and iron deposition in a transgenic model of multiple system atrophy. Experimental Neurology. https://doi.org/10.1016/j.expneurol.2020.113314. Accepted 13 April 2020.

Kuhbandner K, Hoffmann A, Gonzalez Alvarado MN, Seyler L, Bauerle T, Winkler J, Linker RA (2020) alpha-Synuclein: a Modulator During Inflammatory CNS Demyelination. J Mol Neurosci. doi: 10.1007/s12031-020-01498-8

Reyes JF, Sackmann C, Hoffmann A, Svenningsson P, Winkler J, Ingelsson M, Hallbeck M (2019) Binding of alpha-synuclein oligomers to Cx32 facilitates protein uptake and transfer in neurons and oligodendrocytes. Acta Neuropathol 138: 23-47. doi: 10.1007/s00401-019-02007-x

Kuhbandner K, Hammer A, Haase S, Terbrack E, Hoffmann A, Schippers A, Wagner N, Hussain RZ, Miller-Little WA, Koh AY, Stoolman JS, Segal BM, Linker RA, Stuve O (2019) MAdCAM-1-Mediated Intestinal Lymphocyte Homing Is Critical for the Development of Active Experimental Autoimmune Encephalomyelitis. Frontiers in Immunology 10:903. doi: 10.3389/fimmu.2019.00903

Hoffmann A, Ettle B, Battis K, Reiprich S, Schlachetzki JCM, Masliah E, Wegner M, Kuhlmann T, Riemenschneider MJ, Winkler J. Oligodendroglial A-synucleinopathy driven neuroinflammation in multiple system atrophy. Brain Pathol. 2018 Nov 16. doi: 10.1111/bpa.12678.

Hoffmann A, Ettle B, Bruno A, Kulinich A, Hoffmann AC, von Wittgenstein J, Winkler J, Xiang W, Schlachetzki JC. Alpha-synuclein activates BV2 microglia dependent on its aggregation state. Biochemical and Biophysical Research Communications. 2016. 479(4):881-886. doi: 10.1016/j.bbrc.2016.09.109.

Ettle B*, Kuhbandner K*, Jörg S, Hoffmann A, Winkler J, Linker RA. α-Synuclein deficiency promotes neuroinflammation by increasing Th1 cell-mediated immune responses. Journal of Neuroinflammation. 2016. 13(1):201. doi: 10.1186/s12974-016-0694-4. (*contributed equally)

Ardura-Fabregat A, Boddeke EWGM, Boza-Serrano A, Brioschi S, Castro-Gomez S, Ceyzériat K, Dansokho C, Dierkes T, Gelders G, Heneka MT, Hoeijmakers L, Hoffmann A, Iaccarino L, Jahnert S, Kuhbandner K, Landreth G, Lonnemann N, Löschmann PA, McManus RM, Paulus A, Reemst K, Sanchez-Caro JM, Tiberi A, Van der Perren A, Vautheny A, Venegas C, Webers A, Weydt P, Wijasa TS, Xiang X, Yang Y. Targeting Neuroinflammation to Treat Alzheimer’s Disease. CNS Drugs. 2017. 31(12):1057-1082. doi: 10.1007/s40263-017-0483-3.

Marathe HG, Watkins-Chow DE, Wieder M, Hoffmann A, Mehta G, Trivedi A, Aras S, Basuroy T, Mehrotra A, Bennett DC, Wegner M, Pavan WJ, de la Serna IL. BRG1 interacts with SOX10 to establish the melanocyte lineage and to promote differentiation. Nucleic Acids Research. 2017. doi: 10.1093/nar/gkx259

Lehmann CHK, Baranska A, Heidkamp GF, Heger L, Neubert K, Lühr JJ, Hoffmann A, Reimer KC, Beck S, Seeling M, Kießling M, Soulat D, Krug AB, Ravetch JV, Leusen JHW, Nimmerjahn F, Dudziak D. DC subset-specific induction of T cell responses upon antigen uptake via activating or inhibitory Fcγ receptors in vivo. Journal of experimental medicine. 2017. 214(5):1509-1528. doi: 10.1084/jem.20160951.

Heidkamp GF, Sander J, Lehmann CHK, Heger L, Lux A, Eissing N, Baranska A, Lühr J, Hoffmann A, Söder S, Hartmann A, Zenk J, Rogler K, Alexiou C, Spriewald B, Mackensen A, Schuler G, Schauf B, Geiler S, Repp R, Purbojo A, Cesnjevar R, Ullrich E, Nimmerjahn F, Schultze J, Dudziak D. Identification of transcriptional regulators determining tissue localization of human Dendritic cell subpopulations. Science immunology. 2016. 1 (6), doi: 10.1126/sciimmunol.aai7677

Lehmann CH, Heger L, Heidkamp GF, Baranska A, Lühr JJ, Hoffmann A, Dudziak D. Direct delivery of antigens to dendritic cells via antibodies specific for endocytic receptors as a promising strategy for future therapies. Vaccines. 2016. 4(2), 8; doi:10.3390/vaccines4020008

Heidkamp GF, Lehmann CHK, Heger L, Baranska A, Hoffmann A, Lühr J, D. Dudziak D. Functional Specialization of Dendritic Cell Subsets. Encyclopedia of Cell Biology. 2016. Pages 588-604, Elsevier

Hohoff C, Garibotto V, Elmenhorst D, Baffa A, Kroll T, Hoffmann A, Schwarte K, Zhang W, Arolt V, Deckert D, Bauer A. Association of adenosine receptor gene polymorphisms and in vivo adenosine A1 receptor binding in the human brain. Neuropsychopharmacology. 2014. 39(13):2989-99. doi: 10.1038/npp.2014

Kristina Kuhbandner

Graduate student

Department of Neurology
Prof. Ralf Linker

Supervisor

Project Title: The role of alpha-synuclein during inflammatory demyelination and regeneration in the central nervous system

Awards:

Award for the best talk of a Young Scientific Investigators at ECTRiMS (Congress of the European Committee for Treatment and Research in Multiple Sclerosis). Prize money: 1500 €

Title of the talk: “Mucosal addressin cell adhesion molecule 1 mediated intestinal lymphocyte homing is critical for the development of experimental autoimmune encephalomyelitis”.

Publications:

Kuhbandner K, Hoffmann A, Gonzalez Alvarado MN, Seyler L, Bauerle T, Winkler J, Linker RA (2020) alpha-Synuclein: a Modulator During Inflammatory CNS Demyelination. J Mol Neurosci. doi: 10.1007/s12031-020-01498-8

Gonzalez-Alvarado MN, Rotger C, Berger L, London B, Haase S, Kuhbandner K, Lee DH, Linker RA (2020) Functional role of endogenous Kv1.4 in experimental demyelination. J Neuroimmunol 343: 577227. doi: 10.1016/j.jneuroim.2020.577227

Kuhbandner K, Hammer A, Haase S, Terbrack E, Hoffmann A, Schippers A, Wagner N, Hussain RZ, Miller-Little WA, Koh AY, Stoolman JS, Segal BM, Linker RA, Stüve O. MAdCAM-1-Mediated Intestinal Lymphocyte Homing Is Critical for the Development of Active Experimental Autoimmune Encephalomyelitis. Front Immunol. 2019 Apr 26;10:903. doi: 10.3389/fimmu.2019.00903. eCollection 2019.

Hammer A, Waschbisch A, Kuhbandner K, Bayas A, Lee DH, Duscha A, Haghikia A, Gold R, Linker RA. The NRF2 pathway as potential biomarker for dimethyl fumarate treatment in multiple sclerosis. Ann Clin Transl Neurol. 2018 Apr 16;5(6):668-676. doi: 10.1002/acn3.553. eCollection 2018 Jun.

Kuhbandner K. Uncovering the Role of Sox2 in Oligodendroglia. J Neurosci. 2018 May 9;38(19):4460-4461. doi: 10.1523/JNEUROSCI.0556-18.2018.

Ardura-Fabregat A, Boddeke EWGM, Boza-Serrano A, Brioschi S, Castro-Gomez S, Ceyzériat K, Dansokho C, Dierkes T, Gelders G, Heneka MT, Hoeijmakers L, Hoffmann A, Iaccarino L, Jahnert S, Kuhbandner K, Landreth G, Lonnemann N, Löschmann PA, McManus RM, Paulus A, Reemst K, Sanchez-Caro JM, Tiberi A, Van der Perren A, Vautheny A, Venegas C, Webers A, Weydt P, Wijasa TS, Xiang X, Yang Y. Targeting Neuroinflammation to Treat Alzheimer’s Disease. CNS Drugs. 2017 Dec;31(12):1057-1082. doi: 10.1007/s40263-017-0483-3. Review.

Hammer A, Waschbisch A, Knippertz I, Zinser E, Berg J, Jörg S, Kuhbandner K, David C, Pi J, Bayas A, Lee DH, Haghikia A, Gold R, Steinkasserer A, Linker RA. Role of Nuclear Factor (Erythroid-Derived 2)-Like 2 Signaling for Effects of Fumaric Acid Esters on Dendritic Cells. Front Immunol. 2017 Dec 22;8:1922. doi: 10.3389/fimmu.2017.01922. eCollection 2017.

Ettle B*, Kuhbandner K*, Jörg S, Hoffmann A, Winkler J, Linker RA. α-Synuclein deficiency promotes neuroinflammation by increasing Th1 cell-mediated immune responses. J Neuroinflammation. 2016 Aug 26;13(1):201. doi: 10.1186/s12974-016-0694-4.(*contributed equally)

Tania Rizo

Graduate student

Department of Stem Cell Biology
Prof. Beate Winner

Supervisor

Project Title: Modelling Endoplasmic Reticulum Pathology in Hereditary Spastic Paraplegia 4 using human iPSC derived Cortical Motor Neurons

Publications:

Simmnacher K*, Lanfer J*, Rizo T*, Kaindl J*, Winner B (2019) Modeling Cell-Cell Interactions in Parkinson’s Disease Using Human Stem Cell-Based Models. Front Cell Neurosci 13: 571. doi: 10.3389/fncel.2019.00571 * equal contribution

Newton T, Allison R, Edgar JR, Lumb JH, Rodger CE, Manna PT, Rizo T, Kohl Z, Nygren AOH, Arning L, Schüle R, Depienne C, Goldberg L, Frahm C, Stevanin G, Durr A, Schöls L, Winner B, Beetz C, Reid E. Mechanistic basis of an epistatic interaction reducing age at onset in hereditary spastic paraplegia. Brain. 2018 May 1;141(5):1286-1299. doi: 10.1093/brain/awy034.

Allison R, Edgar JR, Pearson G, Rizo T, Newton T, Günther S, Berner F, Hague J, Connell JW, Winkler J, Lippincott-Schwartz J, Beetz C, Winner B, Reid E. Defects in ER-endosome contacts impact lysosome function in hereditary spastic paraplegia. J Cell Biol. 2017 May 1;216(5):1337-1355. doi: 10.1083/jcb.201609033. Epub 2017 Apr 7.

Johann S, Heitzer M, Kanagaratnam M, Goswami A, Rizo T, Weis J, Troost D, Beyer C. NLRP3 inflammasome is expressed by astrocytes in the SOD1 mouse model of ALS and in human sporadic ALS patients. Glia. 2015 Dec;63(12):2260-73. doi: 10.1002/glia.22891. Epub 2015 Jul 21.

Katrin Simmnacher

Graduate student

Department of Stem Cell Biology
Prof. Beate Winner

Supervisor

Project Title: Analyzing the role of aging and alpha-synuclein in the neurodegenerative process of Parkinson´s disease

Publications:

Simmnacher K*, Lanfer J*, Rizo T*, Kaindl J*, Winner B (2019) Modeling Cell-Cell Interactions in Parkinson’s Disease Using Human Stem Cell-Based Models. Front Cell Neurosci 13: 571. doi: 10.3389/fncel.2019.00571

Brazdis RM, Alecu J, Marsch D, Dahms A, Simmnacher K, Lorentz S, Brendler A, Schneider Y, Marxreiter F, Roybon L, Winner B, Xiang W, Prots I (2020) Demonstration of brain region-specific neuronal vulnerability in human iPSC-based model of familial Parkinson’s disease. Hum Mol Genet pii: ddaa039. doi: 10.1093/hmg/ddaa039

Prots I, Grosch J, Brazdis RM, Simmnacher K, Veber V, Havlicek S, Hannappel C, Krach F, Krumbiegel M, Schütz O, Reis A, Wrasidlo W, Galasko DR, Groemer TW, Masliah E, Schlötzer-Schrehardt U, Xiang W, Winkler J, Winner B. α-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathies. Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):7813-7818. doi: 10.1073/pnas.1713129115. Epub 2018 Jul 10., PMID: 29991596

Alexander Urbasik

Graduate student

Department of Biology, Animal Physiology
Prof. Johann Helmut Brandstätter

Supervisor

Project Title: Examining the synaptogenesis and synapse maintenance factor Bassoon as a putative factor for the differential sensitivity of photoreceptors to late-onset degeneration.

Jan Wittstatt

Graduate student

Institute of Biochemistry
Dr. Simone Reiprich

Supervisor

Project Title: Impact of microRNA on the oligodendroglial gene regulatory network

Publications:

Wittstatt J, Weider M, Wegner M, Reiprich S.: MicroRNA miR-204 regulates proliferation and differentiation of oligodendroglia in culture. Glia. 2020 Mar 16. doi: 10.1002/glia.23821. [Epub ahead of print]

Wittstatt J, Reiprich S, Küspert M.: Crazy Little Thing Called Sox-New Insights in Oligodendroglial Sox Protein Function. Int J Mol Sci. 2019 Jun 2;20(11). pii: E2713. doi: 10.3390/ijms20112713. Review.

Reiprich S, Cantone M, Weider M, Baroti T, Wittstatt J, Schmitt C, Küspert M, Vera J, Wegner M (2017). Transcription factor Sox10 regulates oligodendroglial Sox9 levels via microRNAs. Glia 65: 1089-1102.

Stefanie Kempf

Graduate student

Department of Psychiatry and Psychotherapy
Prof. Johannes Kornhuber

Supervisor

Project Title: Interaction of the ASM/ceramide system and TRPC6 channels and its role in plasticity and depression like behaviour

Publications:

Zeitler S*, Ye L*, Andreyeva A, Schumacher F, Monti J, Nürnberg B, Nowak G, Kleuser B, Reichel M, Fejtová A, Kornhuber J, Rhein C, Friedland K: Acid sphingomyelinase – a regulator of canonical transient receptor potential channel 6 (TRPC6) activity. J Neurochem. 2019 Sep;150(6):678-690. doi: 10.1111/jnc.14823. Epub 2019 Aug 22. *equal contribution