MD students
MD students
Julian Alecu
Julian Alecu
Department of Stem Cell Biology
AG Winner
- Email: julian.alecu@fau.de
- Website: http://www.stammzellbiologie.uk-erlangen.de/en/
Project Title: Reducing α-synuclein oligomers as an approach to rescue cell death of iPSC-derived midbrain neurons from patients with Parkinson’s disease
Publications:
Saffari A, Schröter J, Garbade SF, Alecu JE, Ebrahimi-Fakhari D, Hoffmann GF, Kölker S, Ries M, Syrbe S (2021) Quantitative retrospective natural history modeling of WDR45-related developmental and epileptic encephalopathy – a systematic cross-sectional analysis of 160 published cases. Autophagy. doi: 10.1080/15548627.2021.1990671.
Ebrahimi-Fakhari D, Alecu JE, Ziegler M, Geisel G, Jordan C, D’Amore A, Yeh RC, Akula SK, Saffari A, Prabhu SP, Sahin M, Yang E (2021) International AP-4-HSP Registry and Natural History Study. Systematic Analysis of Brain MRI Findings in Adaptor Protein Complex 4-Associated Hereditary Spastic Paraplegia. Neurology.;97(19):e1942-e1954. doi: 10.1212/WNL.0000000000012836.
Ebrahimi-Fakhari D, Alecu JE, Brechmann B, Ziegler M, Eberhardt K, Jumo H, D’Amore A, Habibzadeh P, Faghihi MA, De Bleecker JL, Vuillaumier-Barrot S, Auvin S, Santorelli FM, Neuser S, Popp B, Yang E, Barrett L, Davies AK, Saffari A, Hirst J, Sahin M (2021) High-throughput imaging of ATG9A distribution as a diagnostic functional assay for adaptor protein complex 4-associated hereditary spastic paraplegia. Brain Commun. 2021 Sep 25;3(4):fcab221. doi: 10.1093/braincomms/fcab221.
Jordan C, Geisel G, Alecu JE, Zhang B, Sahin M, Ebrahimi-Fakhari D (2021) Disease Severity and Motor Impairment Correlate With Health-Related Quality of Life in AP-4-AssociatedHereditary Spastic Paraplegia. Neurol Genet. 7(4):e605. doi: 10.1212/NXG.0000000000000605.
Ebrahimi-Fakhari D, Alecu JE, Blackstone C. Spastic Paraplegia 15. 2021 May 27. In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Mirzaa G, Amemiya A, editors. GeneReviews®[Internet]. Seattle (WA): University of Washington, Seattle; 1993–2021. PMID: 34057829.
Eberhardt K, Jumo H, D’Amore A, Alecu JE, Ziegler M, Afshar Saber W, Sahin M, Ebrahimi-Fakhari D. Generation and characterization of six human induced pluripotent stem cell lines (iPSC) from three families with AP4M1-associated hereditary spastic paraplegia (SPG50). Stem Cell Res. 2021 May;53:102335. doi: 10.1016/j.scr.2021.102335. Epub 2021 Apr 16. PMID: 34087981
Simmnacher K, Krach F, Schneider Y, Alecu JE, Mautner L, Klein P, Roybon L, Prots I, Xiang W, Winner B (2020) Unique signatures of stress-induced senescent human astrocytes. Exp Neurol 334:113466.doi: 10.1016/j.expneurol.2020.113466.
Brazdis RM, Alecu J, Marsch D, Dahms A, Simmnacher K, Lorentz S, Brendler A, Schneider Y, Marxreiter F, Roybon L, Winner B, Xiang W, Prots I (2020) Demonstration of brain region-specific neuronal vulnerability in human iPSC-based model of familial Parkinson’s disease. Hum Mol Genet pii: ddaa039. doi: 10.1093/hmg/ddaa039
Monica Bieg
Monica Bieg
Department of Molecular Neurology
Prof. Winkler
Project Title: Activation of myeloid cells in a transgenic mouse model of Huntington’s Disease
Charlotte Billmann
Charlotte Billmann
Institute of Biochemistry
Prof. Lie
Project Title: Activity pattern of canonical Wnt signaling in the postnatal dentate gyrus and expression and role of R-spondin2 in its initiation
Publications:
Heppt J, Wittmann MT, Schäffner I, Billmann C, Zhang J, Vogt-Weisenhorn D, Prakash N, Wurst W, Taketo MM, Lie DC (2020) beta-catenin signaling modulates the tempo of dendritic growth of adult-born hippocampal neurons. EMBO J:e104472.doi: 10.15252/embj.2020104472.
Lia Birschmann
Lia Birschmann
Institute of Biochemistry
AG Karow
Project Title: Studying MID1-mediated microtubule alterations as the underlying cause for aberrant NSC decisions using Opitz G/BBB patient human brain organoids
Timea Gion
Timea Gion
Institute of Biochemistry
AG Lie
- Email: timea.gion@fau.de
- Website: https://www.biochemie.med.fau.de/research/ag-lie-en
Project Title: The impact of Sox11 haploinsufficiency on interneuron development
Fabienne Grolig
Fabienne Grolig
Institute of Biochemistry
AG Lie
Project Title: Investigating the role of FoxO transcription factors in the maintenance of mitochondrial homeostasis in adult neural stem/progenitor cells
Lara Hammad
Lara Hammad
Department of Molecular Neurology
Prof. Winkler
Project Title: The serotonergic innervation of the hippocampus in a transgenic ASM model
Publications:
Kalinichenko LS, Hammad L, Reichel M, Kohl Z, Gulbins E, Kornhuber J, Müller CP. Acid sphingomyelinase controls dopamine activity and responses to appetitive stimuli in mice.Brain Res Bull. 2019 Mar;146:310-319. doi: 10.1016/j.brainresbull.2019.01.026. Epub 2019 Feb 1.
Felicia Himmelsbach
Felicia Himmelsbach
Department of Stem Cell Biology
AG Winner
Project Title: α-synuclein expression and its regulation in lymphocyte subsets
Verena Hundrup
Project Title: Functional maturation of neuronal networks in Noonan Syndrome
Julian Karpf
Julian Karpf
Insitute of Biochemisty
AG Beckervordersandforth
Project Title: Astrocyte heterogeneity in the adult murine dentate gyrus of the hippocampus
Publications:
Karpf J, Unichenko P, Chalmers N, Beyer F, Wittmann MT, Schneider J, Fidan E, Reis A, Beckervordersandforth J, Brandner S, Liebner S, Falk S, Sagner A, Henneberger C, Beckervordersandforth R (2022) Dentate gyrus astrocytes exhibit layer-specific molecular, morphological and physiological features. Nature Neuroscience, 2022 (in press). doi10.1038/s41593-022-01192-5
Schneider J, Karpf J, Beckervordersandforth R (2019) Role of Astrocytes in the Neurogenic Niches. Methods Mol Biol 1938: 19-33. doi: 10.1007/978-1-4939-9068-9_2
Edwina Keck
Edwina Keck
Institute of Biochemistry
Dr. Iris Schäffner
Project Title: Role of FoxO-signaling in postnatal establishment of the adult neural stem cell pool
David Neubauer
David Neubauer
Department of Stem Cell Biology
AG Winner/ Dr. Regensburger
- Email: david.neubauer@fau.de
- Website: http://www.stammzellbiologie.uk-erlangen.de/en/
Project Title: Neuronal iPSC-Model of SPG7-related Hereditary Spastic Paraplegia
Christian Peters
Christian Peters
Institute of Biochemistry
AG Wegner
Project Title: Sox10 regulated expression of important ion channels (Nav1.1,Cav2.2,Kv1.1 & Kir4.1) during oligodendrocyte development
Antonia Schmidt
Antonia Schmidt
Institute of Biochemistry
Prof. Wegner
Project Title: Investigating Gpr37 as a potential target gene of Nkx2.2 and Zfp488 during oligodendrocyte differentiation
Jakob Schmidt
Jakob Schmidt
Institute of Biochemistry
AG Beckervordersandforth
- Email: jakob.johann.schmidt@fau.de
- Website: https://www.beckervordersandforthlab.com/
Project Title: Contribution of astrocyte subtype-specific networks in the dentate gyrus of patients and in mouse model to the pathology of mesial temporal lobe epilepsy
Caroline Swoboda
Caroline Swoboda
Psychiatrische und Psychotherapeutische Klinik
AG Kornhuber
Project Title: Identification of biomarkers in depression