Postdocs & Clinician Scientists

2011 MD, University of Regensburg 2012 M.Sc. (Neurosciences), University of Regensburg since 2011 Resident, Department of Neurology and Postdoctoral Fellow, Department of Stem Cell Biology, FAU Erlangen-Nürnberg

Research focus

Motor neuron diseases comprise a heterogeneous group of neurodegenerative diseases leading to progressive disability. Focusing on amyotrophic lateral sclerosis and hereditary spastic paraplegia, I aim to improve the understanding of the molecular basis of these diseases. To this end, I use patient-derived induced pluripotent stem cells (iPS) and the respective derived neuronal subtypes are analyzed on the cellular and molecular level.

Publications

Leupold L, Sigutova V, Gerasimova E, Regensburger M, Zundler S, Zunke F, Xiang W, Winner B, Prots I. The Quest for Anti-α-Synuclein Antibody Specificity—Lessons Learnt From Flow Cytometry Analysis. Front Neurol. 2022;13:869103. PMCID: PMC9334871 https://dx.doi.org/10.3389/fneur.2022.869103 Utz KS, Kohl Z, Marterstock DC, Doerfler A, Winkler J, Schmidt M, Regensburger M. Neuropsychology and MRI correlates of neurodegeneration in SPG11 hereditary spastic paraplegia. Orphanet J Rare Dis. 2022 Jul 18;17(1):301. PMCID: PMC9336101 https://dx.doi.org/10.1186/s13023-022-02451-1 Regensburger M, Spatz IT, Ollenschläger M, Martindale CF, Lindeburg P, Kohl Z, Eskofier B, Klucken J, Schüle R, Klebe S, Winkler J, Gaßner H. Inertial Gait Sensors to Measure Mobility and Functioning in Hereditary Spastic Paraplegia. Neurology. 2022;99(10):e1079–e1089. PMCID: PMC9519248  https://dx.doi.org/10.1212/wnl.0000000000200819 Krach F, Wheeler EC, Regensburger M, Boerstler T, Wend H, Vu AQ, Wang R, Reischl S, Boldt K, Batra R, Aigner S, Ravits J, Winkler J, Yeo GW, Winner B. Aberrant NOVA1 function disrupts alternative splicing in early stages of amyotrophic lateral sclerosis. Acta Neuropathol. 2022;144(3):413–435. PMCID: PMC9381448  https://dx.doi.org/10.1007/s00401-022-02450-3 Regensburger M, Chaudhry SR, Yasin H, Zhao Y, Stadlbauer A, Buchfelder M, Kinfe T. Emerging roles of leptin in Parkinson’s disease: chronic inflammation, neuroprotection and more? Brain Behav Immun. 2022;107:53–61. PMID: 36150585 https://dx.doi.org/10.1016/j.bbi.2022.09.010 Lanfer J, Kaindl J, Krumm L, Acera MG, Neurath M, Regensburger M, Krach F, Winner B. Efficient and Easy Conversion of Human iPSCs into Functional Induced Microglia-like Cells. Int J Mol Sci. 2022;23(9):4526. PMCID: PMC9105476  https://dx.doi.org/10.3390/ijms23094526 Regensburger M, Krumm L, Schmidt MA, Schmid A, Spatz IT, Marterstock DC, Kopp C, Kohl Z, Doerfler A, Karrasch T, Winner B, Winkler J. Neurometabolic Dysfunction in SPG11 Hereditary Spastic Paraplegia. Nutrients. 2022; 14(22):4803. https://doi.org/10.3390/nu14224803 Peseschkian T, Cordts I, Günther R, Stolte B, Zeller D, Schröter C, Weyen U, Regensburger M, Wolf J, Schneider I, Hermann A, Metelmann M, Kohl Z, Linker RA, Koch JC, Büchner B, Weiland U, Schönfelder E, Heinrich F, Osmanovic A, Klopstock T, Dorst J, Ludolph AC, Boentert M, Hagenacker T, Deschauer M, Lingor P, Petri S, Schreiber-Katz O (2021) A Nation-Wide, Multi-Center Study on the Quality of Life of ALS Patients in Germany. Brain Sci.;11(3):372. doi: 10.3390/brainsci11030372. Schischlevskij P, Cordts I, Günther R, Stolte B, Zeller D, Schröter C, Weyen U, Regensburger M, Wolf J, Schneider I, Hermann A, Metelmann M, Kohl Z, Linker RA, Koch JC, Stendel C, Müschen LH, Osmanovic A, Binz C, Klopstock T, Dorst J, Ludolph AC, Boentert M, Hagenacker T, Deschauer M, Lingor P, Petri S, Schreiber-Katz O (2021) Informal Caregiving in Amyotrophic Lateral Sclerosis (ALS): A High Caregiver Burden and Drastic Consequences on Caregivers’ Lives. Brain Sci.;11(6):748. doi: 10.3390/brainsci11060748. Gaßner H, List J, Martindale CF, Regensburger M, Klucken J, Winkler J, Kohl Z (2021) Functional gait measures correlate to fear of falling, and quality of life in patients with Hereditary Spastic Paraplegia: A cross-sectional study. Clinical Neurology and Neurosurgery, Volume 209, doi.org/10.1016/j.clineuro.2021.106888. Regensburger M, Schlachetzki JCM, Klekamp J, Doerfler A, Winkler J (2020) Long-term course of anterior spinal cord herniation presenting with an upper motor neuron syndrome: case report illustrating diagnostic and therapeutic implications. BMC Neurol 20:321.doi: 10.1186/s12883-020-01891-1. Regensburger M, Stemick J, Masliah E, Kohl Z, Winner B (2020) Intracellular A53T mutant α-synuclein impairs adult hippocampal newborn neuron integration. Front Cell Dev Biol. 2020 Nov 11;8:561963. doi: 10.3389/fcell.2020.561963. eCollection 2020. Pozner T*, Regensburger M*, Engelhorn T, Winkler J, Winner B (2020) Janus-faced spatacsin (SPG11): involvement in neurodevelopment and multisystem neurodegeneration. Brain. BRAIN-2019-01856.R1. *equal contribution Regensburger M (2020) Which kinds of fasciculations are missed by ultrasonography in ALS? Clin Neurophysiol 131: 237-238. doi: 10.1016/j.clinph.2019.09.011 Regensburger M, Minakaki G, Kettwig M, Eisenhut F, Haack T, Kohl Z, Winkler J (2020) Novel biallelic CTSD gene variants cause late-onset ataxia and retinitis pigmentosa. Movement Disorders. Mov. Disord. 2020 May 18. doi: 10.1002/mds.28106. Online ahead of print. Pozner T*, Schray A*, Regensburger M, Lie DC, Schlötzer-Schrehardt U, Winkler J, Turan S, Winner B (2018) Tideglusib Rescues Neurite Pathology of SPG11 iPSC Derived Cortical Neurons. Front Neurosci 2018 Dec 6;12:43. doi: 10.3389/fnins.2018.00914.s001 *equal contribution Pérez-Brangulí F*, Buchsbaum IY*, Pozner T*, Regensburger M, Fan W, Schray A, Börstler T, Mishra H, Gräf D, Kohl Z, Winkler J, Berninger B, Cappello S, Winner B (2018) Human SPG11 cerebral organoids reveal cortical neurogenesis impairment. Hum Mol Genet 2018 Nov 22. doi: 10.1093/hmg/ddy397 *equal contribution Popp B, Krumbiegel M, Grosch J, Sommer A, Uebe S, Kohl Z, Plötz S, Farrell M, Trautmann U, Kraus C, Ekici, AB, Asadollahi R, Regensburger M, Günther K, Rauch A, Edenhofer F, Winkler J, Winner B, Reis A (2018) Need for high-resolution Genetic Analysis in iPSC: Results and Lessons from the ForIPS Consortium. Sci Rep 8, 17201. doi:10.1038/s41598-018-35506-0 Regensburger M, Weidner N, Kohl Z (2018). Motor neuron disease – clinical and genetic differential diagnosis. Nervenarzt, 89, 658–665. doi:10.1038/nn.4000. Regensburger M, Mielenz D, Winner B (2018). Swiprosin-1/EFhd2 – another piece in the puzzle of tauopathy? Aging. doi:10.18632/aging.101431. Editorial. Regensburger M, Prots I, Reimer D, Brachs S, Loskarn S, Lie DC, Mielenz D, Winner B (2018) Impact of Swiprosin-1/EFhd2 on adult hippocampal neurogenesis. Stem Cell Rep 10(2):347-355. Regensburger M, Tenner F, Möbius C, Schramm A (2018) Detection radius of EMG for fasciculations: empiric study combining ultrasonography and electromyography. Clin Neurophysiol 129:487-493. doi: 10.1016/j.clinph.2017.10.037 Regensburger M, Schreglmann SR, Stoll S, Rockenstein E, Loskarn S, Wei Xiang, Masliah E, Winner B (2018) Oligomer-prone E57K- mutant alpha-synuclein exacerbates integration deficit of adult hippocampal newborn neurons in transgenic mice. Brain Struct Funct 223(3):1357-1368. Schneider-Gold C, Dekomien G, Regensburger M, Schneider R, Trampe N, Krogias C, Lukas C, Bellenberg B (2017). Monozygotic twins with a new compound heterozygous SPG11 mutation and different disease expression. J Neurol Sci 381:265-268. doi: 10.1016/j.jns.2017.09.005 Regensburger M, Türk M, Pagenstecher A, Schröder R, Winkler J (2017). VCP-related multisystem-proteinopathy presenting as early-onset Parkinson’s disease. Neurology 89(7):746–8. doi: 10.1212/WNL.0000000000004240 Tenner F*, Regensburger M*, Schramm A, Söhle M, Schwarzkopf K, Zalevsky Z, Schmidt M (2017). Evaluation of a Laser-Based Sensor for the Diagnosis of Neurological Disorders. Conf Proc IEEE Eng Med Biol Soc 2017:4231–4. *contributed equally Schreglmann SR, Regensburger M, Rockenstein E, Masliah E, Xiang W, Winkler J, Winner B (2015) The temporal expression pattern of alpha-Synuclein modulates olfactory neurogenesis in transgenic mice. PLoS One 10(5):e0126261. Madzar D, Hagge M, Möller S, Regensburger M, Lee DH, Schwab S, Jantsch J (2015).Endogenous endophthalmitis complicating Streptococcus equi subspecies zooepidemicus meningitis: a case report. BMC Res Notes 8:184. doi: 10.1186/s13104-015-1133-9 Regensburger M, Huttner HB, Doerfler A, Schwab S, Staykov D (2014). Propofol-related urine discoloration in a patient with fatal atypical intracerebral hemorrhage treated with hypothermia. Springerplus 3:551. doi: 10.1186/2193-1801-3-551 Purohit P, Perez-Branguli F, Prots I, Borger E, Gunn-Moore F, Welzel O, Loy K, Wenzel E, Grömer TW, Brachs S, Holzer M, Buslei R, Fritsch K, Regensburger M, Böhm KJ, Winner B, Mielenz D (2014) The Ca2+ sensor protein Swiprosin-1/EFhd2 is a synaptic protein and involved in kinesin-mediated axonal transport in neurons. PLoS One 18;9(8):e103976. Pérez-Brangulí F, Mishra HK, Prots I, Havlicek S, Kohl Z, Saul D, Rummel C, Dorca-Arevalo J, Regensburger M, Graef D, Sock E, Blasi J, Groemer TW, Schlötzer-Schrehardt U, Winkler J, Winner B (2014) Dysfunction of spatacsin leads to axonal pathology in SPG11-linked hereditary spastic paraplegia. Hum Mol Genet 23(18):4859-74. Schlachetzki JCM, Marxreiter F, Regensburger M, Kulinich A, Winner B, Winkler J (2014) Increased tyrosine hydroxylase expression accompanied by glial changes within the non-lesioned hemisphere in the 6-hydroxydopamine model of Parkinson’s disease. Restor Neurol Neurosci 32(4):447-62. Regensburger M, Prots I, Winner B (2014). Adult hippocampal neurogenesis in Parkinson’s disease: impact on neuronal survival and plasticity. Neural Plast 2014:454696. doi: 10.1155/2014/454696. Review. Marxreiter F, Regensburger M, Winkler J (2013). Adult neurogenesis in Parkinson’s disease. Cell Mol Life Sci. 2013 Feb;70(3):459-73. doi: 10.1007/s00018-012-1062-x. Review. Winner B*, Regensburger M*, Schreglmann S. Boyer L, Prots I, Rockenstein E, ManteM, Zhao C, Winkler J, Masliah E, Gage FH (2012) Role of α-synuclein in adult neurogenesis and neuronal maturation in the dentate gyrus. J Neurosci 32(47):16906-16; *contributed equally Kohl Z, Regensburger M, Aigner R, Kandasamy M, Winner B, Aigner L, Winkler J (2010) Impaired adult olfactory bulb neurogenesis in the R6/2 mouse model of Huntington’s disease. BMC Neurosci 13;11:114. Regensburger M, Kohl Z, Grundmann K, Winner B, Riess O, Winkler J (2009) Adult neurogenesis in transgenic animal models of DYT1 dystonia. Neuroreport 20(17):1529-33.

2017 Resident, Institute of Neuropathology, University of Freiburg 2018 MD, FAU Erlangen-Nürnberg 2018 Resident, Department of Psychiatry and Psychotherapy, University of Freiburg 2019 Resident and Postdoctoral fellow, Department of Molecular Neurology, FAU Erlangen-Nürnberg

Research focus

Microglia are the brain-resident myeloid cells and the main effector cells of the innate immune system in the central nervous system (CNS). Together with other myeloid cell populations, they substantially influence CNS functions under homeostasis as well as in neuroinflammatory and neurodegenerative disorders. Moreover, CNS myeloid cells dynamically respond to peripheral inflammatory challenges. My research focuses on the influence of the peripheral immune system on CNS myeloid cells in health and disease. By using animal models of both inflammatory diseases like rheumatoid arthritis (RA) and neurodegenerative diseases, I aim to elucidate spatiotemporal differences in the vulnerability of the CNS towards peripheral inflammation and develop treatment approaches targeting CNS myeloid cells from the periphery.

Publications

Süß P, Lana AJ, Schlachetzki JCM (2021) Chronic peripheral inflammation: a possible contributor to neurodegenerative diseases. Neural Regen Res 16(9):1711-1714. Utz KS, Martini M, Mrochen A, Lambrecht V, Süß P, Renner B, Freiherr J, Schenk T, Winkler J, Marxreiter F (2021) A Multisensory Deficit in the Perception of Pleasantness in Parkinson’s Disease. J Parkinsons Dis 11(4):2035-2045 Meixensberger S, Kuzior H, Fiebich BL, Süß P, Runge K, Berger B, Nickel K, Denzel D, Schiele MA, Michel M, Maier S, Bechter K, Domschke K, Tebartz van Elst L, Endres D (2021) Upregulation of sICAM-1 and sVCAM-1 Levels in the Cerebrospinal Fluid of Patients with Schizophrenia Spectrum Disorders. Diagnostics (Basel) 11(7):1134. Cattaneo GF, Herrmann AM, Eiden SA, Wieser M, Kellner E, Doostkam S, Süß P, Kiefer S, Fauth L, Maurer CJ, Wolfertz J, Nitzsche B, Büchert M, Jost T, Ihorst G, Haberstroh J, Mülling C, Strecker C, Niesen WD, Shah MJ, Urbach H, Boltze J, Meckel S (2021) Selective intra-carotid blood cooling in acute ischemic stroke: A safety and feasibility study in an ovine stroke model. J Cereb Blood Flow Metab 41(11):3097-3110.

Süß P*, Hoffmann A*, Rothe T*, Ouyang Z, Baum W, Staszewski O, Schett G, Prinz M, Krönke G, Glass CK, Winkler J, Schlachetzki JCM. Chronic peripheral inflammation causes a region-specific myeloid response in the central nervous system (2020). Cell Rep. *equal contribution Kuzior H, Fiebich BL, Yousif NM, Saliba SW, Ziegler C, Nickel K, Maier SJ, Süß P, Runge K, Matysik M, Dersch R, Berger B, Robinson T, Venhoff N, Kessler F, Blank T, Domschke K, Tebartz van Elst L, Endres D (2020) Increased IL-8 concentrations in the cerebrospinal fluid of patients with unipolar depression. Compr Psychiatry 102:152196.doi: 10.1016/j.comppsych.2020.152196 Süß P, Schlachetzki JCM. Microglia in Alheimer’s Disease (2020). Curr Alzheimer Res. doi: 10.2174/1567205017666200212155234. Endres D, Pruss H, Rauer S, Süß P, Venhoff N, Feige B, Schweizer T, Nickel K, Maier S, Egger K, Domschke K, Meyer PT, Tebartz van Elst L (2020) Probable Autoimmune Catatonia With Antibodies Against Cilia on Hippocampal Granule Cells and Highly Suspicious Cerebral FDG-Positron Emission Tomography Findings. Biol Psychiatry 87: e29-e31. doi: 10.1016/j.biopsych.2019.12.020 Endres D, Rauer S, Kern W, Venhoff N, Maier SJ, Runge K, Süß P, Feige B, Nickel K, Heidt T, Domschke K, Egger K, Prüss H, Meyer PT, Tebartz van Elst L (2019). Psychiatric Presentation of Anti-NMDA Receptor Encephalitis. Front Neurol 10, 1086. Lüngen EM, Maier V, Venhoff N, Salzer U, Dersch R, Berger B, Riering AN, Nickel K, Fiebich BL, Süß P, Maier SJ, Egger K, Tebartz van Elst L, Endres D (2019). Systemic Lupus Erythematosus With Isolated Psychiatric Symptoms and Antinuclear Antibody Detection in the Cerebrospinal Fluid. Front Psychiatry 10, 226. Endres D, Süß P, Maier SJ, Friedel E, Nickel K, Ziegler C, Fiebich BL, Glocker FX, Stock F, Lange T, Dacko M, Venhoff N, Erny D, Doostkam S, Komlosi K, Domschke K, Tebartz van Est L (2019). New variant of MELAS Syndrome with Executive Dysfunction, Heteroplasmic Point Mutation in the MT-ND4 Gene (m.12015T>C; p.Leu419Pro) and comorbid polyglandular Autoimmune Syndrome Type 2. Front Immunol 10, 412. Shemer A, Grozovski J, Tay TL, Tao J, Volaski A, Süß P, Ardura-Fabregat A, Gross-Vered M, Kim JS, David E, Chappell-Maor L, Thielecke L, Glass CK, Cornils K, Prinz M, Jung S (2018). Engrafted parenchymal brain macrophages differ from microglia in transcriptome, chromatin landscape and response to challenge. Nat Commun 9, 5206. Süß P, Volz F, Lang C, Staszewksi O, Palmedo G, Taschner CA, Scheiwe C, Kurz P, Mentzel T, Prinz M (2018). A Case of Large Meningeal Epithelioid Hemangioendothelioma With WWTR1-CAMTA1 Gene Rearrangement and Slow Growth Over 15 Years. J Neuropathol Exp Neurol 77, 871-876. Rauer S, Stork L, Urbach H, Stathi A, Marx A, Süß P, Prinz M, Brück W, Metz I (2018). Drug reaction with eosinophilia and systemic symptoms after daclizumab therapy. Neurology 91, e359-e363. Taschner CA, Süß P, Volz F, Urbach H, Dovi-Akué P, Prinz M (2018). Freiburg Neuropathology Case Conference: A Painless Mass Lesion of the Parietal and Occipital Bones. Clin Neuroradiol 28, 301-306. Taschner CA, Süß P, Hohenhaus M, Urbach H, Lützen N, Prinz M (2018). Freiburg Neuropathology Case Conference: Tumor Located in the Anterior Portion of the Third Ventricle. Clin Neuroradiol 28,139-143. Süß P (2017). Remote Control: Impacts of Peripheral Tumor Necrosis Factor-Alpha on Alzheimer Disease-Related Pathology. J Neurosci 37, 8045-8047. Taschner CA, Süß P, Sajonz B, Urbach H, Simon-Gabriel CP, Prinz M (2017). Freiburg Neuropathology Case Conference: Widespread White Matter Lesions in a Patient with Progressive Paraparesis and Cortical Blindness. Clin Neuroradiol 27, 245-250. Süß P, Kalinichenko L, Baum W, Reichel M, Kornhuber J, Loskarn S, Ettle B, Distler JH, Schett G, Winkler J, Müller CP, Schlachetzki JC (2015). Hippocampal structure and function are maintained despite severe innate peripheral inflammation. Brain Behav Immun 49, 156-170.

2010	B.Sc. (Molecular Medicine), Friedrich-Alexander-Universität Erlangen-Nürnberg
2012	M.Sc. (Molecular Medicine), Friedrich-Alexander-Universität Erlangen-Nürnberg
2018	PhD, Institute of Biochemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg
Until 2022	Postdoctoral fellow, Animal Physiology, Friedrich-Alexander-Universität Erlangen-Nürnberg
currently	Postdoctoral fellow, Institute of Biochemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg

Research focus

During development, precise timing of a sequence of transcription factors is necessary to generate the complex neural network of the human brain. A cascade of genetic programs is switched on to control critical developmental steps such as progenitor proliferation, cell cycle exit, fate determination and maturation. Accordingly, genetic mutations of these transcription factors can disturb the correct formation of neural networks and thereby lead to mental diseases. I am investigating the function of the transcription factor SOX11 in human neurodevelopment. Mutations in the human SOX11 gene were identified in patients as a cause for Coffin-Siris-Syndrome. Among other symptoms, Coffin-Siris patients suffer from mental retardation and display autism-like behavior. Using cerebral organoids generated from human pluripotent stem cells and molecular, cell biological and electrophysiological methods I aim to unravel how SOX11 mutations disrupt human brain development.

Publications

Ryl M, Urbasik A, Gierke K, Babai N, Joachimsthaler A, Feigenspan A, Frischknecht R, Stallwitz N, Fejtová A, Kremers J, von Wittgenstein J, Brandstätter JH. Genetic disruption of bassoon in two mutant mouse lines causes divergent retinal phenotypes. FASEB J. 2021 May;35(5):e21520. doi: 10.1096/fj.202001962R Babai N, von Wittgenstein J, Gierke K, Brandstätter JH, Feigenspan A. The absence of functional bassoon at cone photoreceptor ribbon synapses affects signal transmission at Off cone bipolar cell contacts in mouse retina. Acta Physiol (Oxf). 2021 Mar;231(3):e13584. doi: 10.1111/apha Gierke K, von Wittgenstein J, Hemmerlein M, Atorf J, Joachimsthaler A, Kremers J, Cooper BH, Varoqueaux F, Regus-Leidig H, Brandstätter JH. Heterogeneous Presynaptic Distribution of Munc13 Isoforms at Retinal Synapses and Identification of an Unconventional Bipolar Cell Type with Dual Expression of Munc13 Isoforms: A Study Using Munc13-EXFP Knock-in Mice. Int J Mol Sci. 2020 Oct 22;21(21):7848. doi: 10.3390/ijms21217848 Feigenspan A, Ohs A, von Wittgenstein J, Brandstätter JH, Babai N. Analysis of tetrodotoxin-sensitive sodium and low voltage-activated calcium channels in developing mouse retinal horizontal cells. Exp Eye Res. 2020 Jun;195:108028. doi: 10.1016/j.exer.2020.108028 von Wittgenstein J, Zheng F, Wittmann MT, Balta EA, Ferrazzi F, Schäffner I, Häberle BM, Valero-Aracama MJ, Koehl M, Miranda CJ, Kaspar BK, Ekici AB, Reis A, Abrous DN, Alzheimer C, Lie DC. Sox11 is an Activity-Regulated Gene with Dentate-Gyrus-Specific Expression Upon General Neural Activation. Cereb Cortex. 2020 May 18;30(6):3731-3743. doi: 0.1093/cercor/bhz338 Balta EA, Wittmann MT, Jung M, Sock E, Haeberle BM, Heim B, von Zweydorf F, Heppt J, von Wittgenstein J, Gloeckner CJ, Lie DC. Phosphorylation Modulates the Subcellular Localization of SOX11. Front Mol Neurosci. 2018 Jun 19;11:211. doi: 10.3389/fnmol.2018.00211 Balta EA, Schäffner I, Wittmann MT, Sock E, von Zweydorf F, von Wittgenstein J, Steib K, Heim B, Kremmer E, Häberle BM, Ueffing M, Lie DC, Gloeckner CJ. Phosphorylation of the neurogenic transcription factor SOX11 on serine 133 modulates neuronal morphogenesis. Sci Rep. 2018 Nov 1;8(1):16196. doi: 10.1038/s41598-018-34480-x R. Beckervordersandforth, B. Ebert, I. Schäffner, J. Moss, C. Fiebig, J. Shin, D. L. Moore, L. Ghosh, M. F. Trinchero, C. Stockburger, K. Friedland, K. Steib, J. von Wittgenstein, S. Keiner, C. Redecker, S. M. Hölter, W. Xiang, W. Wurst, R. Jagasia, A. F. Schinder, G. L. Ming, N. Toni, S. Jessberger, H. Song, D. C. Lie. Role of Mitochondrial Metabolism in the Control of Early Lineage Progression and Aging Phenotypes in Adult Hippocampal Neurogenesis. Neuron. 2017 Feb 8;93(3):560-573.e6. doi: 10.1016/j.neuron.2016.12.017 A. Hoffmann, B. Ettle, A. Bruno, A. Kulinich, A. C. Hoffmann, J. von Wittgenstein, J. Winkler, W. Xiang, J. C. Schlachetzki. Alpha-synuclein activates BV2 microglia dependent on its aggregation state. Biochem Biophys Res Commun. 2016 Oct 28;479(4):881-886. doi: 10.1016/j.bbrc.2016.09.109 C. Zanden, N. Hellström Erkenstamm, T. Padel, J. Wittgenstein, J. Liu, H.G. Kuhn. Stem cell responses to plasma surface modified electrospun polyurethane scaffolds. Nanomedicine. 2014 Jul;10(5):949-58. doi: 10.1016/j.nano.2014.01.010